Lymphoid pathology II

what are two conditions that cause amyloidosis

plasma cell tumour

bumble foot - chronic inflamamtion

how is amyloid differnet to fibrin

uniform

diffuse

no inflammation or haemorrhage

colour of siderotic/siderofibrotic plaque

grey-white, yellow

species with SCID

horse

dog

mouse

possible genetic cuase of SCID

autosomal recessive - DNA-PKcs gene

X-linked

other things cuasing extra spleen if small

splenic choristoma

splenunculus

what should you target with IHC for thymoma

cytokeratins

stian brown as only thymic eptihelial cells

benign neoplasia of spleen

nodular lymphoid hyperplasia

what are the 4 things that lead to diagnosis of plasma cell tumour multiple myeloma

radiograph shows osteolysis

increased plasma cells in BM

monoclonal gammopathy in electorphoresis

light chian proteinuria with bence-jones

type 1 gallid herpesvirus

infectious laryngotracheitis

how does bovine leukaemia virus occur with enzoonotic leukosis

deltaretrovirus

infectes B cells and encodes oncogenic protein Tax to B cell causing proliferation

2 locations of proliferation in enzoonotic bovine leukaemia

muslce cell bundles

malt lamina propria

symptoms of FeLV

neurological

BM suppression of lineages

immunodeficiency

immune-mediated

stomatitis

3 methods of looking at lymphoma grading

PARR

IHC

look at nuclear size

grooss lymphoma

megaly of organs due to more lymphocytes, pale/tan nodules on cut

thick intestines

2 specific histopathologies of autoimmune IMHA

bone marrow - depletion or hyperplasia

spleen 0 histiocytosis of spleen and haemosiderosis and extramedullary haematopoiesis

babesia histopathology

erythrophagia

present in RBCs - piriforma nd paired

leishmania histo

granulomatous and amastigote in lesion

lymphoid hyperplasia if systemic

lymphoid atrophy if chronic

fungi locations

lymph node

spleen

MALT

what does splenic congestion and intravascular gram positive bacteria indicate in multiple cows

bacillus anthracis

how many types of granulomatous bacteria

4

which aren’t in UK of pyogenic bacteria

fransciella tulerensis

yersinia pestis

corynebacterium

psuedotuberculosis

efffects of haemotropic bacteria grossly

splenomegaly and icterus and conjunctivitis

2 main features histologically of viral issue

lymphoid depletion

lymphocytolysis

large animal viruses

CSF

BVDV

border disese in sheep

equine herpesvirus-1

PRRSV

porcine circovirus 2

what is a splenic infarction

ischaemic necrosis of spleen

why is acute common in spleen

lots of blood spaces

other features of chronic splenic infarction

pale grey/tan

firm

continued chronicity

fibrosis contraction

consistent between acute and chronic infarction of spleen

wedge-shpaed

well-demarcated