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Epigenetics
On top of genes
The effect that the environment around a cell has on gene expression at a molecular level
changes chemicals AROUND DNA sequence, not DNA itself
Stem cells
No yet differentiated into a particular type of cell
Epigenetic tags
Turn genes on or off without changing the DNA itself, just the chemicals around the DNA sequence
most of the inherited epigenetic tags are lost in the early days after fertilization, but some imprinted genes remain
Epigenetics ex: identical twins
Identical twins have the same genome and epigenome, but as they age their environments and signals from the environment activate and silence different genes
Ex. diet, physical activity, exposure to toxins, stress
gene environment correlation
genetic features impact the environment we experience
Environmental features can also change…
the hardwiring of the brain itself
Exp. Sustained stress increases glucocorticoids (GCs), such as cortisol, that at high rates can have negative health effects. Such as negative effects (reduction in size) on the hippocampus, a brain structure crucial for learning and memory
Exp. Being a taxi driver in London requires learning various streets and results in an increased volume of the hippocampus - associated with spatial memory
Extraverts and introverts have different…
Levels of Arousal
What system influences LOA?
ARAS - ascending reticular activation system
Regulates attention, arousal, vigilance, and sleep-wake cycles
how do extraverts and introverts differ in their ARAS activation?
Introverts are easily overstimulated, producing distress and withdrawal
extraverts require more stimulations, and thus tend to seek out more stimulating environments
ex. they may enjoy roller coasters or parties, whereas an introvert may not
what is the OLA
optimal level of arousal for doing a task efficiently
Having too much or too little inhibits performance
Geen found that introverts preferred lower levels of stimulation and performed worse when exposed to high levels of stimulation as compared to extraverts, and vice versa
what is the BIS system associated with
introversion
punishment avoiding
higher activity in the right frontal area of the brain
magnifies reactions to negative events
what is the BAS system associated with
extraverts
reward seeking
higher activity in the left frontal area of the brain
magnifies reactions to positive events
BIS and BAS are on a …
continuum
and are functionally independent, everyone has some levels of both
how reward seeking or punishment avoiding you are can be represented in
differences in brain activation (use)
4 aspects of sensation seeking
measured on SSS, sensation seeking scale - self report, positively associated with OLA
Thrill and adventure seeking
Experience seeking
Disinhibition
Boredom susceptibility
Individuals low on SSS get more stressed when closely confined with another person
Characteristics of high sensation seekers
Risk taking behaviors - varied sexual experiences, drug use, risky driving, risky sports
Intellectual preferences - prefer complexity, have a high tolerance for ambiguity, are more original and creative
Interests and attitudes - liberal, permissive, nonconforming, prefer high stimulation jobs, view love more like a game
biological basis for sensation seeking
Neurotransmitters are chemicals in the nerve cells of the brain and are crucial for transmitting nerve impulses from cell to cell across synapses
Proper level of neurotransmitters is maintained by monoamine oxidase (MAO) which breaks down neurotransmitters after use
Some evidence suggests that high sensation seekers are low in their MAO levels and therefore have higher neurotransmitter levels like epinephrine, norepinephrine, dopamine, oxytocin
LINKED TO OTHER FACTORS
Hormones maintain
Reproduction
Metabolism and energy balance
Growth and development
Body defences
General homeostasis
Purely endocrine hormones
pituitary gland - secretion of many hormones
pineal gland - melatonin
thyroid gland - metabolism
adrenal gland - kidneys, stress, blood pressure
Neurotransmitters vs hormones
Neurotransmitters live in the synaptic gap and produce shorter term effects
hormones are secreted into the blood stream and have longer lasting effects
both require receptors to do anything
what do steroid hormones have in common
Lipid soluble - steroids are they only kind of hormones that can pass through cell membrane without a receptor
other hormones are water-soluble and must bind to receptors on the outside of cell membrane
Produced from cholesterol
Any behaviors that influence cholesterol, influence the levels of these hormones
These hormones can be converted into each other also with a few reactions
When you change serotonin levels it also influences other neurotransmitter systems because they are affiliated
Estrogen, progesterone, testosterone, cortisol
Cortisol is a type of glucocorticoid released from the adrenal glands, important in stress interactions
Testosterone associated with
High levels of testosterone are correlated with negative behaviors such as assault, going AWOL, abusing drugs, having multiple sex partners, and other issues
However, its not ALL testosterones fault, interactions between neurotransmitters, enzymes, hormones, social, and psychological factors are complicated
ex. low education
Biological assessment and change
fMRI allows researchers to trace the relations between activity at the biological level and what the person is doing, thinking, and feeling
PET scans record radioactivity in brain
risky financial decisions associated with
nucleus accumbus region of the brain
The amygdala activates more when
looking at fearful pictures
looking at novel stimuli
more blood flow to amygdala for individuals at age 22 when looking at unfamiliar faces who were inhibited (socially withdrawn) at age 2 - longitudinal study
fMRI vs PET
fMRI traces blood flow via BOLD response to identify relations between neural activity and what a person is doing, thinking, and feeling
PET scans involve injecting a radioactive tracer into the bloodstream that binds to glucose to measure metabolic activity in brain. invasive and usually not preferred unless the research question requires it
what does the amygdala do
almond shaped
Reacts almost immediately to danger signals, sending out behavioral, physiological, and endocrine responses to mobilize the body to fight or flee
fear learning
Seems to be involved with appetitive responses as well
NOT LINKED TO EXTRAVERSION
overactivity in the amygdala is associated with
inhibition and shyness
Adults who were inhibited at age 2 (shy) showed a significant higher increase in blood flow to the amygdala when presented with a novel stimulus vs those who were uninhibited at age 2
Inhibition refers to comfort with social interaction
Early temperamental trait associated with physiological responses
Freud assumed…
You could not count on peoples reports about themselves, you have to interpret what they say
behavior is never accidental but determined by mental motivational causes that are mostly outside of consciousness
psychoanalysis
treatment of inner conflict through dialogue between a therapist and patient
motivational determinism
behavior is never accidental; determined by mental motivational causes
Mental processes can be…
conscious - in one’s attention at a given moment
preconscious - not in ones’s attention but can easily be brought into attentions (ex. background music)
unconscious - unresponsive to deliberate efforts at recall, the main focus of Freud’s work
How can the unconscious be expressed according to Freud?
Dreams - hidden desires we are trying to avoid experiencing consciously
Free association - stereotypical image of a person on the therapists couch saying everything that comes to mind
like TAT, no right or wrong answers
Slips of the tongue - unconscious motives
“bald- I mean boiled egg”
criticisms of freud’s view of extracting the unconscious?
lacked evidence
room for issues with forgetting dreams or incorrectly reporting
highly subjective, based on therapists interpretations
hard to measure
Freud’s personality structure
Id: everything we inherit, life and death instincts
pleasure principle: wants instant gratification and immediate tension reduction
internally oriented
unconcerned with safety and consequences, lives in fantasy
unconscious level
Ego: in direct contact with external world, outgrowth of the id
reality principle: making decisions according to reality, concerned with safety
delayed gratification
internally and externally oriented
deals with unacceptable impulses from id and pressures from superego - mediator
conscious and preconscious
superego: represents the morals and standards attained during development of personality
internalizes parental rules
strives for perfection
on all levels of consciousness
main criticism of freuds personality structure?
too deterministic and hard to measure
biological relevance of freuds personality structure?
Amygdala - Id: intense emotional reactions, especially fearful and appetitive impulses
ex. when you encounter something you fear you don’t care about having an “appropriate reaction”, you just want it to stop
Prefrontal cortex - ego: cool, rational thinking, and executive functions, can shut down inappropriate behaviors
Moral emotions - superego: guilt, empathy, shame, affection
ex. even if nobody sees you steal, you may still feel bad about it
dynamics
the continuous interaction and conflicts between id, ego, and superego
conflicts lead to … which is reduced via…
anxiety, defense mechanisms
defense mechanisms
aim to reduce anxiety in response to conflict
denial and repression are most common
denial
mostly when one cannot escape or attack, happens early on
repression
type of denial, inhibition of impulses
forgetting upsetting / threatening memories
hysterica anesthesia
“loss of sensation” in a body part as a way of diverting impulses with apparently physical symptoms
unresolved conflicts lead to
unresolved conflicts turn into problems like neurotic acts and behavioral signs
focus of behavioral signs?
the focus of behavioral signs is not the behavior itself but the unconscious motivators that might underlie
ex. fear of snakes might indicate a sexual conflict regarding genitals
No quantification or reliable measure of these neurotic behaviors as related to motivations
motives are thought to be rooted in…
early experiences
psychosexual stages
Oral (0 - 1.5) - pleasure centers on mouth
Anal (1.5 - 3) - pleasure centers on imposed control associated with toilet training
Phallic (3 - 5) - genitals, oedipus complex, penis envy or castration anxiety
Latent (6 - 13) - less overt concern with sexuality, “cooties”, bond with own gender
Maturity (13+) - onset of puberty, libido organized around genitals and sexual satisfaction
experiences at psychosexual stages can influence…
later personality traits, potential for arrested development if conflicts remain unsolved
issues with psychosexual stages / psychoanalytic theory
lack of empirical evidence
how do you operationalize libido or unconscious?
too deterministic
little room for change
sexist, ie penis envy
pathologizes relatively normal behavior like envying or admiring mother or father
extremely time consuming
Post freudian psychodynamics paid more attention to
ego and self
social interpersonal causes
later developments throughout the life, past childhood
culture and society
scientific methods - collaboration with other fields like neuroscience and philosophy
gender, race and social standing
shorter durations of therapy
Post freudian psychodynamics paid less attention to
Id and instincts
intrapsychic causes and conflicts
earliest childhood
psychosexual stages
sex and aggression
attachment is found in…
all animals in which infants are initially in need of care
lorenz with ducks imprinting and harlows monkey studies
Behaviorists thought love and attachment are…
a learned response to having one’s needs met
Harlows monkey study challenged this, monkeys preferred a soft cloth mother than a wire mother than provided food
Bowlby’s work on humans showed an innate disposition and evolutionary need for care
How many attachments do humans have?
Multiple, serves as a biological insurance policy
mother, father, grandparents, other relatives, siblings
internal working models in attachment
bowlby theorized we create mental representations of others, the self, or relationships that guide future experiences during early childhood
secure base / safe haven
Caregivers who provide a secure base are responsive to an infant’s needs
and become a safe haven for the child to explore the world.
they make the child feel competent and worthy of affection
proximity maintenance
securely attached infants what to maintain proximity to their caregiver and protest separation
strange situation - mary ainsworth
Toddler is introduced to a playroom, accompanied by the mother and a stranger. The child is exposed to different levels of availability of the mother ranging from involved with child, to mildly preoccupied, to absent. Mother-child interactions are observed, especially at reunion
Attachment styles in infants
Securely attached (60%) - infants were distressed when mother left, but greeted her positively upon reunion and returned to playing
responsive mothers
children who are securely attached are more likely to remain confident on tasks, cope well in absence of parent, delay immediate gratification longer
insecure avoidant (25%) - infants avoided mother when she was present and upon return
mothers varied in responsiveness, unresponsive to bids for attention but overbearing during independent play
insecure ambivalent (15%) - infants were distressed when alone and difficult to comfort when mother returned
mothers inconsistent in responsiveness
what determines attachment style largely?
early experiences with primary caregiver
attachment styles in adult relationships
secure - supportive, trusting, warm families
tend to be satisfied with relationship, believe romantic love can last
lowest loneliness rating in both state and trait
avoidant - aloof, cold, emotionally distant families
cynical of romantic love
ambivalent - many short lived romantic relationships, fearful of loosing partners, believe falling in love is easy but does not last
highest state and trait loneliness
attachment patterns often…
change over time
we learn from previous relationships
current moods or motives can also affect attachment behaviors
role of situation for psychodynamic level?
minimal
ECR-R questionaire
self report measure of variation in close relationships
two sub-scales, avoidance and anxiety
lower scores on both sub scales indicates secure attachment
what attachment style is most lonely
ambivalent
Who focuses more on the function of the id and who focuses more on the ego
freudian psychodynamics focuses on id
post-freudians focus on ego and self
behavioral conditioning level looks at
things we can observe or reliably measure
how is behavioral level different from psychodynamic level?
considers impact of situation
only looks at observed behaviors
behavioral change is motivated by acquiring new experience or modifying old ones
behavioral conditioning perspective on personality
see personality as a collection of learned behaviors
learning
changing physiology and behavior due to acquisitions of new information and experiences
primary biological needs
things like hunger, thirst, sex
secondary needs
things we learn to need via association
money, power, love, creativity
strength of a drive depends on
conditions of deprivation, greater deprivation = stronger drive
classical conditioning
learning associations between cues and responses
when a neutral stimulus is repeatedly paired closely with an unconditioned stimulus that is naturally powerful, it becomes a conditioned stimulus that evokes a conditioned response
ex. UCS = food
UCR = salivating
CS = bell
CR = salivating
cues
determine when, how, and where one will show response
can vary in intensity
4 important factors in learning process
drive
cue
response
reinforcement
higher order conditioning
a new neutral stimulus becomes the conditioned stimulus once associated with old conditioned stimulus and elicits original conditioned response
ex. bowl precedes bell, eventually leads to salivation on its own
neutral stimuli can become aversive when
associated with a traumatic event or outcome
ex. outfit i wore when i failed a test
operant conditioning
outcomes of any freely emitted response determine how likely they are to be repeated
reinforcers increase
punishers decrease
behaviorists will not interpret behaviors as
indicators of motives or inferred attributes
behaviorists emphasize…
the role of situation
ex. Rosenhan and colleagues, presumably mentally healthy individuals, in 1973 admitted themselves to a local mental hospital, complaining of false psychiatric symptoms
Despite their behavior which otherwise remained rational, staff members persistently treated them as if they were psychotic
discrimination versus generalization
discrimination means the ability to tell the difference between two stimuli and only exhibit a particular response to one
stop on red, go on green
generalization means not distinguishing between two stimuli and having the same reaction to both
ex. fear of all furry animals after a bad experience with a dog
can be expected to generalize when a behavior yields similar consequences in many settings
critique of behaviorism
focuses too much on observed behavior and ignores cognitive processes
sometimes behaviors are innate and not learned
largely ignores cultural differences
many of the findings at this level come from animal research which do not necessarily generalize to human behavior
behavioral assessments
focus on specific external conditions and learning processes that might govern behavior
ex. if looking to see why a child uses verbal aggression with peers you may observe the child’s behavior at school to see when verbal aggression is more or less
functional analyses
Introduces an observable and quantifiable change and observes whether or not it produces the expected modification in behavior
Case study: Ann self-isolates to get attention from adults. When adults stopped rewarding this behavior with attention, and only began rewarding her with attention and praise when she played with other children, she stopped self isolating. They reversed this and her behavior reverted to baseline, showing they could change behavior depending on the conditions of reinforcement. Postchecks at random intervals showed that overall this increased her interaction with children and decreased her interaction with adults
wolpe hypothesized that anxiety is …
a conditioned response to stimuli
steps for desensitization
Establishing a hierarchy of severity of anxiety linked to specific situations
Low anxiety: reading a speech alone in your room
Intermediate anxiety: reading a speech to a friend
High anxiety: presenting a speech before an audience
Training an incompatible relaxation response
Ex. deep breathing techniques
Associating anxiety stimuli and incompatible responses
Practicing relaxation responses to the lowest item on the hierarchy and moving gradually to the higher items
what may happen if you have too much reward for a behavior?
the child may lose interest when the external rewards are reduced or stopped altogether
overjustification: excess external reward may interfere with intrinsic motivation that would otherwise be generated by the activity
contingency contract
The person contracts to receive rewards for the desired behavior which are withheld without the desired behavior
An example was Miss X, a heavy user of amphetamines. She gave her therapist $500 (all of her money) in 10 signed checks of $50 each and committed him to send a check to the Ku Klux Klan (her least favorite organization) whenever she violated any step in a series of mutually agreed-upon specific actions for curbing her drug use. After applying the contract for 3 months, a follow-up for a 2-year period indicated that Miss X did not return to amphetamine use.
behavioral therapies criticized as …
just “symptom substitutions” that neglect the roots of issues in favor of modifying the observed behaviors
but it was found that changed behaviors are not automatically replaced by other problematic ones
what are we evaluating at this level
the consequences of behaviors, not the person
Procedure of pineles study
Baseline: measurement of skin conductance with no stimulus
Habitation: conditioned stimulus only
Acquisition: unconditioned stimulus (shock) presented after conditioned stimulus
Extinction: conditioned stimulus presented without unconditioned stimulus
Findings of pineles study
Extraversion facets affect fear acquisition differently
Neuroticism facets have paired influences on fear response
Those more open to feelings maintained or developed stronger differential fear conditioning over acquisition period
Agreeableness facets demonstrate contrasting effects
conscientiousness facets show distinct impacts
main idea of pineles study
Individuals' unique personality and their responses to fear are more intricate and multifaceted than previously thought.
Specific facets within a given personality dimension appear to be differentially associated with fear conditioning