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Prostaglandins
Local hormone-like compounds derived from arachidonic acid
Prostaglandin precursor pathway
Linoleic → arachidonic → prostaglandins, leukotrienes, thromboxanes
Gastric effect
Increase HCl, decrease mucus
Inflammation role
Cause pain, redness, swelling, fever
Clotting role
Regulate platelet aggregation
Aspirin/NSAIDs mechanism
Inhibit prostaglandin production
NSAID effects
Reduce pain, inflammation, fever
NSAID side effects
Increase HCl, decrease mucus → ulcers, reduce clotting