m8 pt. 3 | muscarinic blocking drugs

• atropine and scopolamine (alkaloid)

• Synthetic muscarinic blocking drugs

Classifications under MUSCARINIC BLOCKING DRUGS

Atropine

• From plant Astropa belladoma according to the old books.

• Maybe produced from Datura stramonium

Sopolamine

Produced from Hyoseyamus niger

• Cardiovascular system: causes tachycardia and vasodilation of blood vessels

• Gastrointestinal tract: Relaxes G.I. Tract

• Respiratory system: dilation

• Ocular/Eyes: Mydriasis

• Urinary Bladder: Relaxation

• CNS: Hallucinations

Atropinw and Scopolamine acts on

Twilight Sleep - analgesia and amnesia

Side effects of Atropinw and Scopolamine

• Smooth muscle spasm

• Heaves in Horses (mostly atropine)

• Used as pre-anesthetic

• Treatment of 2nd degree heart block caused by xylazine

• Opthalmic exam

  
  

clinical uses of Atropine and Scopolamine

Anticholinesterase poisoning

Atropine and scopolamine is used as antidote to ______

• glycopyrrolate

• Homatropine

• Methantheline

• Propantheline

• Methyltropine

Synthetic Muscarinic Blocking Drugs

Glycopyrrolate

Does not cause tachycardia

Homatropine

• is almost the same as atropine but there is a change in ester in which it contains mandelic acid instead of tropic acid.

• mas maganda compared sa atropine

Methylatropine

almost the same as atropine, but it has a methyl group.