Midterm 2: First-Line Agents

uUTI

Nitrofurantoin

TMP-SMX

Fosfomycin trometamol

cUTI

3rd Gen Cephalosporin (Ceftriaxone, Ceftazidime, etc.)

4th Gen Cephalosporin (Cefepime)

Carbapenem (Ertapenem, Meropenem)

Fluoroquinolone (Ciprofloxacin, Levofloxacin)

Aminoglycoside (Gentamicin, Tobramycin)

Penicillin + B-lactamase INH (Piperacillin-tazobactam)

MDRO cUTI

Combo or Novel Cephalosporin

Asymptomatic Bacteriuria in Pregnancy

Cephalexin

Amoxicillin

Amoxicillin-clavulanate

Recurrent UTI

Nitrofurantoin

Cephalexin

TMP-SMX

Acute Bacterial Prostatitis

Ceftriaxone

Ciprofloxacin, Levofloxacin

TMP-SMX

Chronic Bacterial Prostatitis

Doxycycline

Ciprofloxacin, Levoflocacin

TMP-SMX

CA-BSI Gram Positive Cocci Empiric

Vancomycin IV, Daptomycin IV

CA-BSI Gram Negative Rod Empiric

Cefepime

Piperacillin-tazobactam

Meropenem

Coag neg staph CA-BSI

Vancomycin IV

MRSA CA-BSI

Vancomycin IV

MSSA CA-BSI

Cefazolin IV, Oxacillin IV

Pseudomonas aeruginosa CA-BSI

Cefepime

Piperacillin-tazobactam

Meropenem

E. coli, Klebsiella spp. CA-BSI

Beta-lactam

Ceftriaxone IV

Candida CA-BSI

Fluconazole

Candida glabrata, krusei CA-BSI

Micafungin IV

Native Valve Endocarditis MSSA

Oxacillin/Nafcillin

Cefazolin

Native Valve Endocarditis MRSA

Vancomycin IV

Daptomycin IV

Native Valve Endocarditis Streptococcus spp.

Penicillin IV

Ampicillin IV

+Gentamicin

Native Valve Endocarditis Enterococcus spp.

Ampicillin + Gentamicin IV

Prosthetic Valve Endocarditis MSSA

Oxacillin/Nafcillin + Rifampin + Gentamicin

Prosthetic Valve Endocarditis MRSA

Vancomycin + Rifampin + Gentamicin

Uncomplicated Apendicitis Operative

Cefazolin + Metronidazole

Uncomplicated Apendicitis Non-Operative

Ceftriaxone + Metronidazole

Ciprofloxacin + Metronidazole

Uncomplicated Cholecystitis Operative

Cefazolin

Uncomplicated Cholecystitis Non-Operative

Ceftriaxone

Ciprofloxacin

Uncomplicated Diverticulitis

Ciprofloxacin + Metronidazole

Primary Peritonitis

Ceftriaxone + Metronidazole

Spontaneous Bacterial Peritonitis PPX

Ciprofloxacin

Secondary Peritonitis Treatment Low Risk

Ceftriaxone + Metronidazole

Secondary Peritonitis Treatment High Risk

Piperacillin-tazobactam

Cefepime + Metronidazole

Acute Bacterial Rhinosinusitis

Amoxicillin-clavulanate

HD Amoxicillin-clavulanate

Group A Streptococcal Pharyngitis (Strep Throat)

Penicillin V

Amoxicillin

Benzathine penicillin G

Acute COPD Exacerbation Low Risk Pseudomonas

Amoxicillin-clavulanate

Tetracycline

Macrolide (Azithromycin, Clarithromycin)

Acute COPD Exacerbation High Risk Pseudomonas

Levofloxacin, Ciprofloxacin