RBC Diff Practice

Bacterial infection=inc WBC, left shift, toxic vac, toxic gran, dohle bodies, intracellular bacteria

viral infection=inc or dec WBC, atypical lymphs, normal RBC + plt count

IDA/Thal/Pb poisoning=micro/hypo, thal-targets, baso stipp, Pb- heavy baso stipp, can’t differentiate based on PS alone

Rh incompatibility=increased NRBCs, poly, macro/normo

ABO incompatibility=increased spherocytes, poly, macro/normo

B12/Folate=macro/normo, hypersegs, oval macro, pancytopenia, PA madness

Anemia of Liver Disease=round macro, targets, acantho, stomatocytes

Anemia of Chronic Renal Insufficiency=burr cells, norm/norm

Anemia of Chronic Disease

norm/norm, increased Fe

Acute Blood Loss

inc WBC, inc plt, decreased clotting time, decreased Hgb/Hct after few hours, inc retics

Chronic Blood Loss

leads to IDA, micro/hypo over time

SS=sickle cells/drepanocytes, targets, HJB b/c autosplenectomy

CC=lots of targets, c crystals

SC=sickle cells, more targets, purse cells, SC crystals

Malaria=intraerythrocytic parasites, vivax most common, falciparum most deadly

Infectious mononucleosis=increased lymphs w/ atypical/downey lymphs

Multiple myeloma=plasma cell—blue cytoplasm with perinuclear Hof

Chediak higashi=giant peroxidase + deposits, large red granules in segs, also in lymphs

Chediak higashi=giant peroxidase + deposits, large red granules in segs, also in lymphs

Sickle cell=drepanos and target cells, howell jolly bodies

IDA=micro/hypo, aniso and poikilo

Auer rod+basket cell=leukemia

Pelger-Huet=pince-nez, bilobed, not clinically significant

Alder-reilly=dark granulation in granulocytes, lymphs, monos—-precipitated mucopolysaccharides

Hereditary elliptocytosis=not clinically significant

Hereditary Spherocytosis=hemolytic anemia, jaundice, splenomegaly, aplastic crisis

PA=hyper seg, oval macrocytes, macro/normo, pancytopenia

May-hegglin=dohle like bodies in granulocytes, large bizarre plts