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GERD
Weak LES → acid reflux | Heartburn + regurgitation | Clinical diagnosis; endoscopy if alarm signs | PPI + lifestyle | Barrett esophagus
Acute Pancreatitis
Premature enzyme activation → autodigestion | Epigastric pain radiating to back | Lipase ≥3× ULN + RUQ US | IV fluids + analgesia + early feeding | Necrosis/shock
Acute Cholecystitis
Cystic duct obstruction → inflammation | RUQ pain + fever + Murphy sign | RUQ US first | IV fluids + analgesia + antibiotics + early lap cholecystectomy | Perforation
Acute Cholangitis
CBD obstruction → bile stasis + bacterial infection | Fever + RUQ pain + jaundice | CBC + LFTs + blood cultures + RUQ US | IV fluids + IV antibiotics + ERCP | Sepsis