4003 Genetics - Module 9 Quiz

Which of the following is not a function of heterochromatin formation?

Gene silencing 

Prevention of transposable element movement 

Removal of histones

Prevention of viral proliferation

Removal of histones

Due to imprinting, the Igf2 gene is activated because ______________  of the ICR and DMR _________ occur during _____________.

covalent histone modification, does, oogenesis

DNA methylation, does not, spermatogenesis

DNA methylation, does, spermatogenesis

DNA methylation, does not, oogenesis

DNA methylation, does, spermatogenesis

Which of the following is involved in regulating gene transcription in eukaryotes?

Pioneer factors

HOTAIR

RISC (RNA-induced silencing complex)

Both A and B are involved in transcriptional regulation.

Both A and B are involved in transcriptional regulation.

Which of the following is not one of the steps of X inactivation that occurs during embryonic development in female mammals?

Binding and spreading of Xist RNA along the inactivated chromosome 

Expression of the Tsix gene on the inactivated X chromosome

X chromosome pairing

Shifting of the pluripotency factors and CTCFs to the active X chromosome

Expression of the Tsix gene on the inactivated X chromosome

The main role of the trithorax group complexes is to

cause X-chromosome inactivation.

cause gene activation in specific cell types.

activate genes in response to certain environmental agents.

remove histone proteins during the elongation phase of transcription.

cause gene activation in specific cell types.

The A^vy allele of the Agouti gene involves the insertion of a transposable element upstream from the normal Agouti promoter. The transposable element carries a promoter that causes the over expression of the Agouti gene. Mice carrying this allele tend to have coat colors that are more yellow than mice that don’t have this transposable element. If pregnant female mice are fed a diet that contains chemicals that increase DNA methylation, how would you expect that this diet would affect the coat color of offspring carrying the A^vy allele?

Their fur would be more yellow because the Agouti gene would tend to be over expressed.

Their fur would be more yellow because the Agouti gene would tend to be under expressed.

Their fur would be less yellow (more dark brown) because the Agouti gene would tend to be over expressed.

Their fur would be less yellow (more dark brown) because the Agouti gene would tend to be under expressed.

Their fur would be less yellow (more dark brown) because the Agouti gene would tend to be under expressed.

In the image below, the ncRNA is acting as a

decoy 

guide

 scaffold

 blocker

 

scaffold

Which of the following are components that HOTAIR ncRNA can bind to?

 

PRC2 complex, LSD1 complex, and GA-rich regions

PRC2 complex, LSD1 complex, and miRNA 

PRC2 complex, miRNA, and GA-rich regions

PRC2 complex only

 

PRC2 complex, LSD1 complex, and GA-rich regions

Which of the following is not one of the steps in RNA interference (RNAi) that occurs with miRNA (microRNA)?

 

Uptake of Pri-miRNA from the environment

Cleavage of pre-miRNA by dicer

Binding of miRNA to form RISC

Binding of RISC to a complementary mRNA

Uptake of Pri-miRNA from the environment

Which genes of the CRISPR-Cas system are not needed for the expression and interference phases?

 

Cas1, Cas2

Cas9

tracr

 Crispr

Cas1, Cas2

Which of the following topics is not a topic for the Progress Report on Commercialization?

 

Potential funding

Company personnel

Potential revenue

Future plans for other gene editing

 

Future plans for other gene editing