Heterophile Antibody & EBV

Heterophile antibodies are antibodies that react with antigens from __________ unrelated species.

two or more

Epstein-Barr virus (EBV) is associated with infectious mononucleosis, Burkitt's lymphoma, and __________ carcinoma.

nasopharyngeal

The presence of heterophile antibodies, along with classic symptoms of IM, helps diagnose __________.

infectious mononucleosis

Antibodies to specific EBV antigens can differentiate between current, past, and __________ infection.

reactivated EBV

EBV is transmitted via direct contact with infected __________.

saliva

The Monospot test involves mixing patient serum with __________ red blood cells.

sheep

The Mono-diff test differentiates IM heterophile antibodies from others by using a series of absorptions with __________ kidney cells.

guinea pig

The IM immunochromatographic assay uses a related heterophile antigen bound to colored __________ erythrocyte antigen.

bovine

Sensitivity of heterophile antibody tests for IM is around __________%.

85-90

False-negative results in IM tests can occur in about __________% of patients, especially early in the infection.

10-15

Follow-up testing can be done using EBV-specific antibody tests if a rapid IM test is __________.

negative

Rheumatic fever typically develops __________ weeks after a Streptococcus pyogenes infection.

1 to 3

Antibody testing is preferred over antigen testing for sequelae of streptococcal infections because the bacteria are often __________ present.

no longer

The ASO titer detects antibodies against __________, a toxin produced by Streptococcus pyogenes.

streptolysin O

The presence of anti-DNase B is detected using __________ immunoassays or nephelometric methods.

enzyme

The Streptozyme test detects antibodies to five different streptococcal __________.

antigens