Pulmonary Disease Chapter 29: Guillian-Barre Syndrome (GBS)

Guillian-Barre Syndrome

an auto-immune disease that causes an acute peripheral nervous system disorder that results in a flaccid paralysis of the skeletal muscles and loss of muscle reflexes

diaphragmatic paralysis and ventilatory failure

how does GBS affect the respiratory system in severe cases?

demyelination of the myelin sheath

the pathology of GBS is characterized by inflammation and deterioration of the peripheral nervous system. Name the specific pathological process.

True

True or False: GBS is thought to be caused by an immunologic attack

IgM

what antibodies will be elevated in GBS?

IgM antibodies

these antibodies are your bodies first line of defense against infections

True

True or False: GBS patients will feel symmetric muscle weakness in the distal extremities accompanied by paresthesia or dysesthesias

pins and needles; tingling

translate the word paresthesia to layman's terms

FALSE: In GBS, muscle paralysis is ASCENDING; That is, it starts at the feet and moves upward (Ground Up)

True or False: GBS muscle paralysis is descending

-Lumbar puncture (CSF)

-Electromyography (EMG)

-Nerve conduction studies (NCS)

name 3 ways to diagnose GBS

-diminished

-crackles

name 2 breath sounds in GBS

failure to expectorate due to muscle paralysis

why would we hear crackles in GBS?

yes

could a GBS patient be cyanotic?

-Maximum inspiratory force (NIF/MIP)

-Forced Vital Capacity (FVC)

-Maximum Expiratory Pressure (MEP)

name 3 measurements we must closely monitor as part of GBS management

less than -20

what value should maximum inspiratory pressure be?

20 cc/kg IBW

forced vital capacity must be no less than...

plasmapheresis

entails the removal of damaged antibodies from the patients blood plasma, followed by the transfusion of the blood cells