HIV AND AIDS

HIV IS CATEGORIZED UNDER WHAT FAMILY?

RETROVIRIDAE

WHAT IS THE SUBFAMILY OF HIV

LENTIVIRINAE

HIV INFECTS HUMANS AND WOULD ATTACK THE IMMUNOCOMPETENT CELLS SPECIFICALLY WHAT CELLS?

CD4+ CELLS

THIS SERVES AS THE GATEWAY FOR VIRUSES TO ENTER CELLS

CD4+

CD4+ ARE FOUND IN THE SURFACE OF THE?

T HELPERS/INDUCERS

THIS IS THE MOST IMMUNOCOMPETEMT CELLS IN THE IMMUNE SYSTEM

T-HELPER/INDUCERS

HIV HAS A MARKED PREFERENCE FOR T-HELPER/INDUCER LYMPHOCYTES, WHICH SERVES AS THE ___ FOR THE VIRUS

RECEPTOR SITES

WHAT ARE THE VIRAL GENE PRODUCTS OF “GROUP ANTIGEN GENE”

P24, P18, P15

THIS GENE CODES FOR CORE STRUCTURAL PROTEIN

P24, P18, P15

VIRAL GENE PRODUCT OF POLYMERASE GENE

REVERSE TRANSCRIPTASE, RNASE, PROTEASE, INTEGRASE

THIS IS THE MOST POTENT ENZYME IN THE VIRAL STRUCTURE BECAUSE THIS IS CAPABLE OF TRANSCRIBING THE SSRNA I THE VIRION TO BECOME DSDNA

REVERSE TRANSCRIPTASE

THIS TRANSCRIBES SSRNA INTO DSDNA

REVERSE TRANSCRIPTASE, RNASE, PROTEASE

THIS IS RESPONSIBLE FOR THE PRODUCTION OF ENZYMES WITH VARIOUS FUNCTIONS

POLYMERASE GENE

THIS IS RESPONSIBLE FOR INSERTING VIRAL DNA INTO HOST DNA

INTEGRASE

WHAT ARE THE VIRAL GENE PRODUCTS OF ENVELOPE GENE

GP160 AND GP41

GP160 IS THE COMBINATION OF?

GP120 AND GP41

THIS IS WHERE GP120 ORIGINATES

GP160

THIS BINDS TO CD4 RECEPTORS FOR INFECTION

GP160

THIS IS REQUIRED FOR VIRAL FUSION OF CELL

GP41

THESE ARE THE ANTIGENS THAT ARE TESTED IN THE LABORATORY WHENEVER WE DO SCREENING AND CONFIRMATORY TEST FOR HIV

GP160 AND GP41

ALL ARE MODE OF TRANSMISSION OF HIV, EXCEPT:

A. SEXUAL CONTACT

B. KISSING

C. BLOOD TRANSFUSION

D. PARENTERAL INJECTION

E. TRANSPLACENTAL

F. BREASTFEEDING

G. PASSAGE THROUGH INFECTED BIRTH CANAL

B

MODE OF TRANSMISSION FOR HIV WITH THE HIGHEST RISK OF INFECTION

SEXUAL CONTACT

TRUE OR FALSE. MODE OF TRANSMISSION FOR HIV IS SIMILAR WITH THE MODE OF TRANSMISSION IN HEPATITIS B

TRUEC

CLINICAL MANIFESTATION. WHAT STAGE?

PATIENT IS EITHER ASYMPTOMATIC OR MAY SHOW LYMPHADENOPATHY

PRIMARY STAGE

CLINICAL MANIFESTATION. WHAT STAGE?

IM LIKE SIGNS AND SYMPTOMS

PRIMARY STAGE

IN THE INTERMEDIATE STAGE, THIS STATE IS KNOWN AS THE?

AIDS-RELATED COMPLEX

CLINICAL MANIFESTATION. WHAT STAGE?

LOW T-CELL COUNT

INTERMEDIATE STAGE

CLINICAL MANIFESTATION. WHAT STAGE?

QUANTITATIVE T CELL DEFICIENCIES WITH INVERTED CD4:CD8 RATIO (FLIPPED PATTERN)

INTERMEDIATE STAGE

CLINICAL MANIFESTATION. WHAT STAGE?

SEVERE DEPLETION OF HELPER-INDUCER T LYMPHOCYTES

INTERMEDIATE STAGE

WHAT IS THE NORMAL CD4:CD8 RATIO?

2:1

CD4:CD8 RATIO IN AIDS PATIENT

0.5:1

CLINICAL MANIFESTATION. WHAT STAGE?

2-10 YEARS AFTER INITIAL INFECTION

FINAL/END STAGE

CLINICAL MANIFESTATION. WHAT STAGE?

A SYNDROME OF CD4 DEPLETION RESULTING IN OPPORTUNISTIC INFECTIONS AND CANCERS SUGGESTIVE OF CELL MEDIATED IMMUNITY DEFECTS AND ANTUBODY PRODUCTING CAPABILITY OF THE INDIVIDUAL

FINAL/END STAGE

HIV+ AND AID ARE DIFFERENTIATED BASED ON?

CD4+ CELL COUNT PER UL OF BLOOD

WHAT IS THE NORMAL CD4 COUNT OF HEALTHY INDIVIDUALS?

500-1400 CELL/UL OF BLOOD

WHAT IS THE CD4 COUNT OF HIV+ INDIVIDUALS

LESS THAN 500 BUT MORE THAN 200 CELL/UL OF BLOOD

WHAT IS THE CD4 COUNT OF INDIVIDUALS WITH AIDS AND HIV

BELOW 200 CELLS/UL OF BLOOD

WHAT TYPE OF HERPES SIMPLEX WHEN THE UPPER WAIST IS THE ONE INFECTED

TYPE 1 HERPES SIMPLEX

WHAT TYPE OF HERPES SIMPLEX WHEN THE LOWER WAIST IS THE ONE INFECTED

TYPE 2 HERPES SIMPLEX

WHAT IS THE BASIC MANIFESTATION OF AN IMMUNOCOMPROMISED STATE?

PATIENT IS EASILY INFECTED WITH FUNGAL INFECTIONS

TUMORS IN THE SKIN AND LININGS OF INTERNAL ORGANS, LYMPHOMAS, AND CANCERS OF RECTUM AND LUNG

KAPOSI’S SARCOMA

THIS IS THE MOST FREQUENT MALIGNANCY OBSERVED

KAPOSI’S SARCOMA

KAPOSI’S SARCOMA IS CAUSED BY A?

HUMAN HERPES VIRUS TYPE 8

FIRST ANTIBODY TO BE DETECTED IN KAPOSI’S SARCOMA WHICH PERSISTS THROUGHOUT THE INFECTION

ANTI-GP41

THE MOST WIDELY USED SCREENING TEST FOR HIV ANTIBODIES

INDIRECT ELISA

ALL ARE SCREENING TESTS FOR HIV ANTIBODY, EXCEPT:

A. INDIRECT ELISA

B. ELISA (COMPETITIVE ASSAY)

C. INDIRECT IMMUNOFLUORESCENT ASSAY

D. SLIDE AGGLUTINATION TEST

E. RIA

F. IMMUNOCHROMATOGRAPHIC METHOD

C

MOST WIDELY USED SUPPLEMENTARY TEST FOR CONFIRMING REACTIVE HIV ELISA AB TEST

WESTERN BLOT

IN WESTERN BLOT TESTING, IF THE GP41 BAND APPEARS ALONE OR WHEN AN ENVELOPE AB APPEARS IN COMBINATION WITH ANOTHER HIV BAND, WE REPORT IT AS?

A. NEGATIVE

B. POSITIVE

C. INVALID

B

IN WESTER BLOT TESTING, IF NO BANDS APPEAR, WE REPORT IT AS?

A. NEGATIVE

B. POSITIVE

C. INVALID

A

IN WESTERN BLOT, THE ANTIGENS OF THE VIRUS ARE INTEGRATED AND HARVEST IN A?

NITROCELLULOSE ACETATE STRIP

IN WESTERN BLOT, THE NITROCELLULOSE ACETATE STRIP WITH THE VIRUS’ ANTIGEN WILL BE INCUBATED IN THE?

PATIENT’S SERUM

IN WESTERN BLOT, AFTER THE INCUBATION OF THE STRIP TO THE PATIENT’S SERUM, IT WILL BE INCUBATED AGAIN, BUT THIS TIME IN THE?

ENZYME/BIOTIN CONJUGATED AHG

WHAT ARE THE TESTS FOR DETECTING HIV GENES?

IN SITU HYBRIDIZATION, FILTER HYBRIDIZATION, SOUTHERN BLOT HYBRIDIZATION, DNA AMPLIFICATION, PCR

THIS TESTS FOR HIV RNA (NUCLEIC ACID OF THE VIRUS)

POLYMERASE CHAIN REACTION