patho- SPIROCHETES

borrelia is gram __

negative, spriochetes

for borellia, ___ are required for transmission to humans

vectors

b. burgdorferi causes ___ disease

lyme

most common vector borne diseasein the us

lyme

b. burgdorferi has an ______ protein __ that allows for binding to ______

O surface protein A, mindgut of unfed ticks

b. burgdorferi has an outer surface protein C that is _______ during tick blood meal

upregulated

borrelia lyme has a _____ rash. begins as _____ infection

bullseye, localized

lyme ____ develops in the majority of untreated patients

arthritis

most common diagnostic method for b. burgdorferi

antibody detection

Borrelia recurrentis is spread by the human body __

louse

B. recurrentis happens when lice feed on an ____ person. human infection happens when lice are ______ while feeding.

infected, crushed

B. recurrentis causes relapsing ____ and ___ return after a week

fever, bacteremia

leptospira is extremely ____, and an obligate __

motile, aerobe

two types of hosts for leptospira

reservoir (endemic), incidental (humans, person to person not documented)

leptospira, because of its motility can spread _____, and damage ____ of blood vessels

everywhere, epithelium

leptospira infection through skin abrasions, causes flu like symptoms that can progress to severe disease

leptospirosis

icteric form of lectospirosis, associated with higher mortality. hepatic necrosis and red eyes

Weil disease

mistaken for viral meningitis, in CNS, low mortality rate of leptospira

leptospirosis in the CNS

treponema pallidum is the etiological agent of

syphilis

T. pallidum enterse through _____ abrasions. local multiplication causes infiltration of _____, ___, ____

skin. plasma cells, PMNs, macrophages

syphilis causes ___ nodes. spontaneous healing can occur

inguinal

secondary syphilis causes ____ illness or ____ in lymph nodes, liver, joints etc

flu like, lesions

what can occur after secondary syphilus

latent

latent syphilus is when its ______ after secondary and the treponemas _____

dormant, multiply

tertiary syphilis is a ____ disease. causes syphilus in ____ or ___ systems.

destructive. neuro or cardio

congenital syphilus causes facial and _____ deformaties

tooth

congenital syphilus can infect baby ____

in utero