Determination of the ionophoretic premability of human skin

what is ionophresis also called?

Medical electrophoresis

What is ionophoresis / medicinal electrophoresis?

method by which ionic substances are introduced in the body through the skin using electric current

what kind of membrane is the skin?

a porous electrochemically active membrane

what does ion movement depend on?

pores radii, character of the double electrical layer

what has to be taken into account in medicinal electrophoresis?

physical and chemical parameters of medicinal solutions, conditions of the procedure , skin morpho - functional state

how does skin permability differ?

Different in different regions, for different types of ions and individuals becuase each ion type skin permeability is characterised by the quantity ionophorectic permeabiltity.

Explain the formula K = m/QS

K= Quantity of ionophoretic permability m= mass of introduced ion, Q = total electric charge of ions , S = skin area ( which ion s have been introduced)

What is necessary to determine the exact dosage of medicinal substance?

• Knowlege of the patients skin ionophoretic peremability value

• number of procedures and conditions they may know of

what happens during ionophoretic permeability determination?

a solution of medicinal substance concentration c1 and volume is placed in a cuvette. After electrophoresis its concentration c2 is determined again. Part of the substance is introduced thriugh the skin .

which concentration is higher C1 or C2?

concentration C2 is always lower than C1

How can the concentration change be found?

by Titration or measurement of solution electrical conductivity

what is solute mass equal to?

to concentration multiplied by volume of the solution

what is the formula for the mass of a substance introduced through the skin by electrophoresis

m = ( c1 - c2) V

what is the Formula for electric charge introduced during a procedure pf duration at a constant current ?

Q = It

What is the formula for the skin area through which ions are introduced ?

S = pid²/4

what is d?

the diameter of cuvette opening

what are the saftey measures?

• Report any damaged insulation

• Dont touch the experimental setup

• Dont make any changes in the circuit when its energized