Onco Exam 2 Pearls

Procarbazine

lipophilic

PO

Cisplatin

ototoxic, nephrotoxic

OCT2

Carboplatin

more tolerable version

DLT= myelo

Oxaliplatin

Colorectal cancer

increased permeability within class

Methotrexate

DHFR inhibitor

Polyglutamated by FPGS

5-FU

<15min

colorectal cancer

DPD deficiency toxicity

Capecitabine

prodrug

colorectal cancer

Cytarabine

blood cancers

DLT= GI, neuro

Gemcitabine

Pancreatic cancer

Mercaptopurine

XO activated

TPMT deficiency toxicity

Fludrabine

Immunosuppressive warning

Cladribine

Blood cancers (B-cell)

Vinblastine

Hepatic excr./adj.

HL, NHL, Breast cancers

DLT= alopecia

Vincristine

blood cancers

add prednisone

DLT= neuropathy, SIADH

Vinorelbine

Lung (NSC) cancer

Semisynthetic

PO

DLT= neuropathy

Paclitaxel

BRoad

DLT= myelo, neuropathy

Docetaxel

DLT= myelo, neurotoxic, fluid

Topotecan

Renal excr./adj.

Ovarian cancer

Irinotecan

Hepatic excr./adj.

potent

DLT= diarrhea, myelo

Etoposide

Renal excr./adj.

PO

Germ cell cancers

Doxorubicin

Hepatic excr./adj.

*red fingernails/fluid/etc.

DLT= myelo, GI, cardio!

Daunorubicin

Hepatic excr./adj.

acute myeloleukemia

*red fingernails/fluid/etc.

DLT= myelo, GI, cardio

Idarubicin

Hepatic excr./adj.

acute myeloleukemia

*red fingernails/fluid/etc.

DLT= myelo, GI, cardio

Mitoxantrone

Hepatic excr./adj.

blue fingernails/fluid/etc.

DLT= myelo, GI, cardio

Bleomycin

renal excr./adj.

DLT= pulmonary fibrosis