Glucocorticoid induced OP

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Last updated 5:32 PM on 8/16/26
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10 Terms

1
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Majority of bone loss occurs within ____ months of glucocorticoid use

3-6 months

2
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What percent of patients have evidence of vertebral fracture

40%

3
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True or false: fracture risk reverses with the d/c of GC

true

4
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What GC is used as a reference point? What is the GIOP risk?

prednisone 2.5mg or more on a daily basis for 3+ months

5
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What are the glucocorticoids (examples)?

  • prednisone

  • hydrocortisone

  • methylprednisolone

  • dexamethasone

6
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What is the mechanism of GIOP?

  • promote bone resorption

  • inhibit bone formation

7
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Bone loss results from increases in expression of what?

RANKL

8
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What does the increased expression of RANKL lead to?

increased number of bone-resorbing osteoclasts

9
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There is decreases in bone formation early in GC treatment becuase…

decrease in osteoblast recruitment

10
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When assessing BMD with VFA/spinal x-ray and patient is less than 40, what score should be used?

z-score