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non-communicable disease (NCD)
not passed from person-to-person
also known as chronic disease
long duration and slow progress
-diseases of “old age”
-cause morbidity, disability, and premature mortality
collectively responsible for 74% of all deaths worldwide
limited curability (management)
complex etiology
etiology of NCD
generally no specific etiological agent
-combination of multiple risk factors
-genetic predisposition
-lifestyle
multiple risk factors
-non-modifiable risk factors: age, gender, race, genetics
-modifiable risk factors: physical inactivity, unhealthy diet, smoking, alcohol use
cardiovascular, diabetes, cancer, and chronic respiratory
4 non-communicable diseases
undernutrition
results in disease
children especially susceptible
lower immunity→ increase infectious disease
overnutrition
results in disease
possible toxicities with some vitamins (especially fat soluble)
excess calories can promote obesity
obesity
excess of body fat (adipose tissue)
defined by BMI or other measures
-weight in kg / (height in meters)²
adjust according to muscle mass (ex. athletes) or bone density (ex. elderly)
other measures include: waist circumference, waist-to-hip circumference ratio, skin fold thickness, imaging techniques
causes of obesity
imbalance of energy input vs energy output
excess energy converted to adipose tissue
complex mix of behavioral and biological factors
interventions of obesity
lifestyle modifications
-reducing caloric intake
-increasing physical activity
medications
-fat absorption inhibitors
-appetite suppressants
-GLP-1 receptor agonists
surgery
-several procedures to reduce stomach capacity
mechanical stress, metabolic syndrome, and hormonal imbalances
pathological consequences of obesity
mechanical stress
sleep apnea
osteoarthritis
breathing difficulties
back pain
metabolic syndrome
high blood glucose
high blood pressure
dyslipidemia
hormonal imbalances
low grade inflammation
some cancers
reproductive disorders
mood disorders