lipid drugs

statin

atorvastatin, rosuvastatin, simvastanin, pravastatin

atorvastanin MOA

inhibits hmg-coa reductase, decreasing cholesterol synthesis in the liver and lowering LDL

atorvastatin use

lowering LDL and reducing ascvd risk

benefits or atorvastatin

decreased risk of MI and stroke, stabilize arterial plaques

adrs for atorvastatin

muscle pain and weakeness, GI upset, increased liver enzymes, rhabdomyolysis

considerations for statins

monitor lipids, assess for muscle pain/weakeness, dark urine

cholesterol absorption inhibitor

esetimibe

ezetimibe

decreases cholesterol absorption in small intestine increases hepatic LDL receptors and lowering LDL

benefits of ezetimibe

additional LDL lowering, lowers risk of ascvd further

ezetimibe adrs

diarrhea, abdominal pain, fatigue, myopathy

PCSK9 inhibitors

alirocumab, evolocumab

alirocumab

blocks pcsk9 and lowering LDL

use for alirocumab

pt with ascvd or severe hypercholesteremia

adrs for alirocumab

injection site reaction, flu like symptoms, nasopharyngitis

give sub Q

bile acid sequestrants

bind bile acids in intestine to lower LDL

bile acid sequestrants adr

constipation, bloating

niacin

decreases TG and LDL, may increase HDL

niacin adrs

flushing, increased blood glucose, liver toxicity

prescription omedga 3 fatty acids

decrease TG production

fibrates

fenofibrate, gemfibozil

fenofibrate

activates PPAR-a and reduces TGs

benefits of fenofibrate

significantly lowers TG

can increase HDL and reduce pacreatitis risk

what is used to treat hypertriglyceridemia

fibrates/prescription omega 3s

dyslipidemia is treated with

statins

athersclerosis is treated with

statins (atorvastatin)

ezetimibe

alirocumab

hypertriglyceridemia is treated with

statins (atorvastatin)

fibrates of PO3 for TG elevation

peripheral artery disease is treated with (meds)

statins (atorvastatin), antiplatelet therapy (i.e. aspirin)

CAS is treated with

antiplatelets - apirin or clopidogrel

statin - atorvastatin