antivirals , antifunguls , antihelminths

First line anti tuberculosis drugs

RIPE

Rifampicin

Isoniazid

Pyranizamide

Ethambutol

First line for tuberculosis and cuases visual side effects

Ethambutol

Second line for tuberculosis

Moxiflaxacin

Bedaquiline

Linezolid

A 14 year old presents with fever

Nuchal rigidity   , in a csf sample gram negative dicoci is seen ,she sleeps in the same room as her siblings .

What should be does to help protect the siblings

Rifampicin used for MENENGITIS PORPHYLAXIS

Gram negative coci = N. Menengitis

Anti herpes agents and thier toxicity

Acyclovir : renal toxicity🫘 Thymidine kinase

    -Ganciclovir : First line for CMV  ( Mylesuppresion )

    *Bone marrow toxicity 🦴

    -Forscarnet : If CMV is resistant. Or herpes is resistant        Forscarnet is used

• nephro toxicity   Kindey🫘

• HYPOcalemia and hypomagnesemia

HIV ART drug tenefovir is toxic for what

Nephro toxic 🫘AND bone toxic🦴

Anti hepatitis B

Tenofovir - entecavir

Anti hep C

velaptasvir  - sofosbuvir - garzopravir

Influenza Both A and B Are given what

Oseltamivir

Only infuenza A , Also used in Parkinson’s ( Dyskinesia )

Amantadine

When mother begins labour , prevents HIV transmission from mother to child

Nevirapine

used in RSV (respiratory syncytial infections )

Ribaverin

MoA of acyclovir

Thymidine kinase inhibition

Antiviral that inhibit nueraminidase budding and release

Oseltamivir

Acyclovir resistant HSV is given what drug and why does it work

Foscarnet

Explanation

Foscarnet directly inhibits viral DNA polymerase

Antiviral causes bone marrow suppression

Ganciclovir

Superficial candidas first line

Nustatin

amphotrecin B MoA

And sides

Ergosterol or fungal cell wall

Sides : Nephrotoxicity 🫘with HYPOkalemia ⬇

aspergilosis 🫁 First line

Voriconazole

• Azoles ) Flucoconazole -Itraconazole

Ends with -conazole What is thier MoA

Block ergesterol

Used for fungal menengitis

Flococonazole

2nd line for candidas and aspergillosis

Echinocandins

Dermatophytes treatments and what is thier MoA

Terbinafine

MoA : Blocks sequel epixidase

Which antifungal inhibits ß-1,3-D-glucan synthase?

Caspofungin

Explanation

Echinocandins like caspofungin inhibit

B-1,3-D-glucan synthase.

Pin worms first line of treatment and second

Pyrantel pamoate : Pin worms (enterbius vermicularis )

2nd : albendazole , mebendazole

Wide spectrum antihelminth used also for Hook worms

Albendazole - mevendazole

Ivermecten uses

strongyloids  , onchocerca (riverblindness)

Diathelcarbamazine  ( DEC)

Wuchereria bankrofti ( Filariasis )

2.Loa loa

What is given to schistoma parasite

causes 1.portal hypertention

2. Squamous cell carsinoma in the bladder

Praziquantel

• TISSUE TAGERING

Metronidazole - Tinidazole - ornidazole

• Lumial agents ( prevent relapse ) for the cysts

Paromomycin  - lodoquinol -diloxanide furoate

Systemic disease

tissue agents then luminal ( metronidazole then parmomycin )

Liver abcess

Metronidazole ( high dose ) THEN parmomycin

IF ASYPTOMATIC

ONLY lumial agents ( parmomycin - lodoquinol-diloxanide  )

What causes is metronidazole uses in

Amebas :

Giardia : string test for diagnosis

Thromoniasis :the most common NON VIRAL SEXUALLY TRANSMITTED DISEASE

In women : foul smelling  discharge

In men : asymptomatic

E. DISPAR Is given what

DOES NOT REQUIRE ANTOBIOTICS

Trypnomasomiasis Sleeping sickness

T. Gambienese : 1st stage - PENTAMIDINE

                              2nd stage - NECT

                              (Nifortimox - elfirnithine )

T. Reodesienese  : 1st stage :suramin

                                2nd stage : melarsopol

FAXINIDAZOLE : approved for both

Pneumonic  :

Gambia 🇬🇲 1st pentagon 2nd NECT

Road, sura ,melar

Veciral lieshmaniasis first line

Amphotrecin B

Treatment options forAll types of lieshmaniasis

Sodium stibogluconate  - All types

meglumine antimonate - All types

Miltefosine : ORAL OPTION

Taxoplasmosis First line

Pyramethamine + sulfadiazine + leucovorin

Taxoplasmosis drug that prevents done suppretion

Leucovorin

Used for taxoplasmosis before infection is conformed

Spiramycin

Toxoplasmosis prophylaxis in HIV

trimethoprim - sulfamethoxazole

TMP -SMX***

What drug offers single dose traetment for giardaia

Tinidazole