Phosphatidylinositol Second Messenger System IP3

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Last updated 2:59 AM on 3/18/25
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6 Terms

1
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STEP 1

The ligand binds to its receptor, activating the G protein

2
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STEP 2

The Alpha subunit binds and activates phospholipase C (PLC)

3
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STEP 3

PLC converts PIP2 to DAG and IP3

DAG and IP3 stimulate different parts of the cascade at the same time

4
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STEP 4

IP3 moves into the cytosol

5
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STEP 5

Causes the release of calcium from the endoplasmic reticulum

6
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STEP 6

Calcium will stimulate contraction/secretion OR it can bind with Calmodulin-→ physiological change