Endo Exam 2: Master Comparison Table of Non-Diabetic Drugs

Which class are these medications?

• Glucophage

• Glucophage XR

• Glumetza

• Riomet soln (metformin)

Biguanide

Which class are these medications?

• Diabeta

• Glynase (glyburide)

• Amaryl (glimepiride)

• Glucotrol

• Glucotrol XL (glipizide)

Sulfonylureas

Which class are these medications?

• Starlix (nateglinide)

• Prandin (repaglinide)

Meglitinides

Which class are these medications?

• Actos (pioglitazone)

• Avandia (rosiglitazone)

TZDs

Which class are these medications?

• Invokana (canagliflozin)

• Farxiga (dapagliflozin)

• Jardiance (empagliflozin)

• Steglatro (ertugliflozin)

• Brenzavvy (bexagliflozin)

SGLT2i

Which class are these medications?

• Nesina (alogliptin)

• Tradjenta (linagliptin)

• Onglyza (saxagliptin)

• Januvia (sitagliptin)

DPP-4i

Which class are these medications?

• Victoza (liraglutide)

• Trulicity (dulaglutide)

• Ozempic (semaglutide SQ)

• oral semaglutide ("oral Ozempic")

GLP-1 RA

Which class are these medications?

• Mounjaro (tirzepatide)

GLP-1/GIP RA

Which class are these medications?

• Precose (acarbose)

• Glyset (miglitol)

alpha-glucosidase-i

Which class are these medications?

• Cycloset (bromocriptine)

DA agonist

Which class are these medications?

• Welchol (colesevelam)

BAS

Which class(es) of meds has the MOST A1c Decrease?

GLP-1/GIP RA

Medication class with the Highest Hypoglycemia Risk?

Insulin

Medication classes with the Moderate or High Hypoglycemia Risk?

Sulfonylureas and Meglitinides

Which med classes result in weight LOSS?

Biguanide, SGLT2i (1-5 kg), and GLP-1/GIP RA

Which med classes result in the GREATEST weight loss?

GLP-1/GIP RA

Which med classes result in the weight GAIN?

Sulfonylureas, Meglitinides, TZDs, and Insulin

Key AEs of: GI (N/D), ↓ B12

Biguanide

Key AEs of: Hypoglycemia, weight gain, rare derm rxn

Sulfonylureas

Key AEs of: Hypoglycemia

Meglitinides

Key AEs of: Edema, HF, fractures, bladder CA (pio), macular edema

TZDs

Key AEs of: GU/yeast infections, dehydration, DKA, fractures, Fournier's

SGLT2i

Key AEs of: Pancreatitis, HF (alogli/saxa), arthralgia, bullous pemphigoid

DPP-4i

Key AEs of: GI (N/V/D/C), pancreatitis, gallbladder, retinopathy

GLP-1 RA

Key AEs of: Same as GLP-1; ↓ oral contraceptive effect

GLP-1/GIP RA

Key AEs of: Hypoglycemia, weight gain, lipodystrophy

Insulin