anatomy and physiology of RBC

what is the function of blood

transport, regulation, defense

what are the differences in cat and horse erythrocyte cell size

cat has 66.7 ml/kg while horse has 71.7 ml/kg

what are the differences in cat and horse cell number

cat has 6-8 while horse has 7-10

what are the differences in cat and horse cell lifespan

cat cell lifespan is 70-80 days while horse is 140-150 days

explain the process of development from pluripotent stem cell to mature blood cells

pluripotent stem cell - myeloid and lymphoid stem cells - myeloid splits into all blood cells but lymphocyte

what does hemoglobin has a greater affinity for

CO Thus Hb will preferentially reacts with CO to form carbonmonoxyhaemoglobin

How are erythrocytes removed from circulation

intravascular hemolysis, extravascular hemolysis, mononuclear phagocytic or macrophage system

How does intravascular hemolysis remove RBC from circulation

aged cell lyse, Hb binds to plasma protein haptoglobin, engulfed by cells of mononuclear phagocytic or macrophage system, and recycled

How does intravascular hemolysis remove RBC from circulation

cellular fragments and aging erythrocytes directly engulfed by cells of MPS

where are mononuclear phagocytic or macrophage system located in domestic animal

red bone marrow

where are mononuclear phagocytic or macrophage system located in human

spleen

where are mononuclear phagocytic or macrophage system located in birds and some other animals

liver

what are the components required to support erythropoiesis

amino acids, lipids, carbs, iron, folic acid, vitamin B12

how is iron regulated in the body

reuptake from ingested sources, stored in body as ferritin

why is folic acid needed for RBC production

used for DNA and RNA syntheis

why is vitamin B12(cobalt) important for RBC production

used for maturation of erythrocytes and formation of DNA

why is Cobalt import for ruminant diet

used for bacterial synthesis of vitamin B12

How is erythropoiesis regulated

erythropoietin (EPO) deceased O2 delivery to kidney, stimulates increased EPO production

what are the three types of anemia

hemorrhagic, hypoproliferate, hemolytic

what is acute hemorrhagic anemia

external/internal bleeding, coagulation disorders (warfarin, sweet clover), intestinal parasites

what is chronic hemorrhagic anemia

GI lessions, coagulation disorders (vitamin K deficiency hemophilia), ectoparasites

what is hypoproliferative anemia

decreased erythropoiesis due to dietary deficiencies, destruction of bone marrow, bracken poisoning

what are the dietary deficiencies in hypoproliferative anemia

iron, hypochromic anemia and vitamin B12/folic acid- megaloblastic anemia

what are the ways that bone marrow can be destroyed to cause hypoproliferative anemia

irradiation, X rays, certain chemicals, myeloproliferative disorders

what is hemolytic anemia

destruction of erythrocytes

how can hemolytic anemia be caused

blood parasites, bacterial infections, chemicals and drugs, poisonous plants and venoms, immune mediated