Block 1 Pharma

Propofol (Diprivan) (drug of week)

GABA agonist, allows Cl- to flood and hyperpolarize neurons in CNS

Lidocaine (Xylocaine)

Blocks Na channels and hyperpolarizes cells

Allopurinol (Zyloprim)

Xanthine Oxidase Inhibitor; Antigout

Colchicine (drug of week)

Prevents cytoskeleton formation (inhibits tubulin polymerization). Anti-mitotic drug (prevent activation/degranulation/migration of neutrophils) to decrease inflammation in gout

Probenecid

Inhibits reabsorption of uric acid in proximal tubule of the kidney

NSAIDs

Non-selective COX1 and COX2 inhibitor

Hydroxyurea (drug of week)

Inhibits DNA synthesis in highly proliferative cells (blocks ribonuclease reductase) halting cells in S phase

Imatinib

Tyrosine kinase inhibitor (competitive inhibitor for ATP)

DasaTINIB, niloTINIB, bosuTINIB

2nd gen TK inhibitor (higher affinity=Higher toxicity)

PonaTINIB

3rd gen TK inhibitor used for the T315I mutation in CML

Amoxacillin

prevent crosslinking of PBP in bacteria, cells walls can't form, bacteria die

Doxycycline (Vibramycin, doryx)

Binds 30s ribosome in bacteria, preventing protein production (bacteriostatic)

Ceftriaxone (drug of the week)

Beta-lactam structure binds bacterial enzymes needed for proper cell wall production

Ondansetron (Zofran)

blocks serotonin (5-HT3) receptors in the vomiting center of the brain (postrema) and in the NTS

Morphine

opioid receptor agonist. Binds GPCR, opens K channels and closes Ca channels

Pyridostigmine (drug of week)

Acetylcholinesterase inhibitor, increase ACTH in NMJ. Tx of myasthenia gravis

Lactulose

osmotic laxative. Breaking down lactulose in the intestine lowers the Ph in the lumen and traps ammonia in the intestine.

Heparin

Allosteric activation of antithrombin which inhibits factor Xa and thrombin

Low Molecular Weight Heparin (LMWH, enoxaparin)

Allosteric activator of antithrombin, but can only help it inhibit factor Xa because it is smaller than normal Heparin

Omeprazole (drug of week)

Proton pump inhibitor (covalent binding of cystine residues via disulfide bridges on alpha subunit of H/K ATPase. Inhibits gastric acid secretion for 36h

Acetaminophen (Tylenol) (Drug of week)

Unknown MOA, thought to indirectly inhibit COX and selectively inhibit COX3 variant. No peripheral inti-inflammatory effects

Synthetic Growth Hormone (somatotropin) (Drug of week)

GH receptor agonist (JAK/STAT)

Insulin (RAPID)

Aspart, glulisine, lispro

Insulin (SHORT)

regular

Insulin (INTERMEDIATE)

NPH

Insulin (LONG)

Glargine, detemir

Methotrexate

folate antagonist

Can cause megaloblastic anemia

tx: cancer, RhA, Psoriasis,

Ectopic pregancy

RhoGAM

Add foreign antibodies to the mother so her immune system doesn't create them for herself

Sodium benzoate

Nitrogen scavenger, conjugates with glycine and removes it from the nitrogen pool

Phenolbuterate/ phenolacetate

Nitrogen scavengers