RX523 Pharmacokinetics in Patients with Malnutrition

What are the indicators of malnutrition in pediatric patients?

- Handgrip strength

- Tanner Stage

- Deceleration in weight-for-height z-score

What are the key points of marasmus?

- Inadequate energy intake of all forms

- Wasting

- Weight-for-height is decreased

- Fat and somatic protein stores are decreased

- Serum protein concentrations and immune function may be normal

What are the key points of kwashiorkor?

- Inadequate energy intake of protein

- Edema

- Weight-for-height is normal or increased

- Fat and somatic protein stores are increased

- Serum protein concentrations and immune function are decreased

What are the absorption changes in malnutrition?

- Decreased P-gp activity

- Decreased IM or SUBQ absorption

What are the distribution changes in malnutrition?

- Reduced albumin concentrations

- Altered alpha-1 acid glycoprotein

What are the metabolism changes in malnutrition?

- Decreased hepatic blood flow

- Impaired Phase I and II metabolism

- Increased half-life

- Decreased total drug clearance

A patient with severe malnutrition associated with reduced protein energy intake may present with decreased Scr. What is the predicted impact on the estimated CrCl calculation using Cockcroft-Gault?

Overestimated CrCl

Match the criteria below with the category of GLIM criteria to which they belong in the assessment of malnutrition in adults.

Weight loss

Phenotypic

Match the criteria below with the category of GLIM criteria to which they belong in the assessment of malnutrition in adults.

Reduced muscle mass

Phenotypic

Match the criteria below with the category of GLIM criteria to which they belong in the assessment of malnutrition in adults.

Inflammation

Etiologic

Which of the following is most likely to decrease in patients with malnutrition, particularly protein energy malnutrition?

Albumin concentrations