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Kinetic energy
energy of motion or energy associated with movement
Potential energy
Stored energy that depends on the structure of an object or its position relative to a field or its surroundings
Chemical energy
form of potential energy held in the chemical bonds between pairs of atoms in a molecule
metabolic pathway
A series of linked chemical reactions in which molecules are built up or broken down, where the product of one reaction serves as the reactant for the next
Adenosine Disphosphate (ADP)
chemical relative of ATP composed of ribose, adenine, and two phosphate groups, containing less chemical energy than ATP
First Law of thermodynamics
Also known as the law of conservation of energy, it states that energy cannot be created or destroyed, only converted from one form to another, leaving the total amount of energy in the universe constant
Entropy
The degree of disorder in a system, or a measure of the number of possible positions and motions available to a molecule
Second Law of thermodynamics
principle stating that every energy transformation is associated with an increase in the entropy (disorder) of the universe
Gibbs Free energy
The amount of energy available to do work in a system or reaction
Exergonic
Describes spontaneous chemical reactions with a negative change in free energy (delta G) that release energy available to do work
Endergonic
non-spontaneous chemical reactions with a positive change in free energy (delta g) that require a net input of energy
Energetic Coupling
A process in which a spontaneous (exergonic) reaction drives a non-spontaneous (endergonic) reaction22. It requires the sum of the free energy changes (delta) for the combined reactions to be negative and usually involves a shared intermediate molecule2223
Catabolism
set of metabolic chemical reactions that breaks down molecules into smaller units, releasing energy and often producing ATP from ADP and inorganic phosphate
Anabolism
set of metabolic chemical reactions that builds molecules from smaller units, requiring an input of energy typically provided by ATP
Enzyme
protein that acts as a biological catalyst to accelerate the rate of a chemical reaction in a cell without being consumed
Catalyst
substance that increases the rate of a chemical reaction without being consumed in the process or altering the reaction's equilibrium
Transition state
highly unstable intermediate state between reactants and products that has the highest amount of free energy during a chemical reaction
Activation energy
The initial input of energy required for reactants to reach the transition state and overcome the energy barrier to proceed
substrate
specific reactant molecule that binds to an enzyme in a catalyzed reaction
Active site
specific region of a folded enzyme that binds the substrate and catalyzes its conversion to product
Denature
process by which a protein or enzyme unfolds and loses its three-dimensional structure, causing it to completely lose its biological function
Activator
A molecule that binds to an enzyme and increases its activity
Inhibitor
molecule that binds to an enzyme and decreases or stops its activity
Allosteric site
region on an enzyme distinct from the active site where regulatory molecules, such as allosteric inhibitors or activators, bind to alter enzyme shape and activity[16]