Derm Exam 1 Elder

What is the HLA Allele for Abacavir and associated Reaction ?

HLA-B 57:01 and Hypersensitivity reaction

What is the HLA Allele Alloprinol and Associated Reaction?

HLA-B 58:01 SJS/TEN and Dress

What is the HLA Allele for Carbamazepine and associated reaction?

HLA-B 15:02 SJS?TEN

HLA-A 31:01 SJS?TEN Maculopapular Exanthema

What is the HLA Allele for Phenytoin and associated reaction?

HLA-B 15:02 SJS TEN

What happens to patients that test Positive for HLA 15:02 ?

Avoid Carbamazepine Unless Benefits outweigh risks of severe reactions.

what happens to patients that test postive for HLA-A 31:01?

weight the risks and benefits before prescribing.

Typical Onset for SJS/TEN

1-4 Weeks

Typical Onset for Dress?

2-8 Weeks

Main Presentation SJS/TEN

Skin Pain

Blistering

epidermal Detachment

Mucosal Involvement

Main Presentation Dress

Widespread rash, Facial, Edema, Fever, Eosinophilia

Systemic SJS/TEN

Fluid Loss - Infection - organ complication

Systemic for Dress

Internal Organ Injury, especially the LIVER

Medical emergency Requiring Hospitalization

SJS/TEN

Assess Severity and organ Involvement

Dress