GPCR Effectors

Gα_i subunit acts on what effector(s)?

Adenylyl cyclase

Gα_s subunit acts on what effector(s)?

Adenylyl cyclase and calcium channels

Gα_q subunit acts on what effector(s)?

Phospholipase C and GIRK channels

Gα₁₂ subunit acts on what effector(s)?

Rho GEF

Where does Gβγ come from?

Gi, adenylyl cyclase (-)

Gβγ subunit acts on what effector(s)?

Calcium channels, GIRK channels, phospholipase C, and adenylyl cyclases

How does Gα_i affect adenylyl cyclase?

Inhibitory

How does Gα_s affect adenylyl cyclase?

Activates

How does Gα_s affect calcium channels?

Activates

How does Gα_q affect phospholipase C?

Activates

How does Gα_q affect GIRK channels?

Inhibits

How does Gα₁₂ affect Rho GEF?

Activates

How does Gβγ affect calcium channels?

Inhibits

How does Gβγ affect GIRK channels?

Activates

How does Gβγ affect phospholipase C and adenylyl cyclases?

Activates and inhibits

What is the consequence of Gα_i inhibiting adenylyl cyclase?

cAMP and PKA activity is decreased

What is the consequence of Gα_s activating adenylyl cyclase?

Increased cAMP and PKA activity & relaxation

What is the consequence of Gα_s activating calcium channels?

Pre-synaptic activation

What is the consequence of Gα_q activating phospholipase C?

Increased Ca⁺⁺ and PKC activity & contraction

What is the consequence of Gα_q inhibiting GIRK channels?

Post-synaptic activation

What is the consequence of Gα₁₂ activating Rho GEF?

Cytoskeleton regulation

What is the consequence of Gβγ inhibiting calcium channels?

Pre-synaptic inhibition

What is the consequence of Gβγ activating GIRK channels?

Post-synaptic inhibition

What is the consequence of Gβγ activating/inhibiting phospholipase C, adenylyl cyclase?

Regulation of cAMP, Ca⁺⁺, PKC