Bone

What is the matrix of bone?

Collagen

what is an Osteocyte?

mature bone cell that maintains matrix

what is an Osteoblast?

builds new bone

what is an OsteoCLAST cell?

multinucleanated cell that breaks down bone for remodeling

what does an Osteogenic cell do?

divides and differenciates into osteoblasts

Bone ECM equation:

collagen(osteoid)+Ca2+

How is bone broken down?

Osteoclast secretes HCl from macrophages

What is osteogenesis/ossification?

Formation of bone

What does an osteocyte do?

maintains bone tissue

What is Intramembranous Ossification? Produces what?

mesenchymal tissue forming bone without cartilage during fetal development, dermal bones

Why/How are there holes in bone? Spongy Bone

Osteoblast form around blood vessels and once matured, leaves holes

What is Endrochondral Ossification? Most bones need to start with what? What increases the amount of cartilege?

ossification WITH cartilage, hylaine cartilege, chondrocytes

Red bone marrow is in? Source of what? As you age, it is replaced by what?

flat bones and spongy ends of long bones, hemopatic cells, adipose tissue

Yellow bone marrow is..

where fat is stored

Epiphyseal plates are..

growth plates made from hylaine cartilege, site of new bone growth till adulthood

Appositional growth means BLANK, growth for BLANK

Interstitial growth means BLANK, growth for BLANK

adding new layers to existing tissues, width, chondrocytes divide and produce new matrix within tissue, length

Calcium excreted from stool/urine may be linked to..

kidney complications

A lack of Vitamin B12 can lead to BLANK which can cause BLANK

In general it..

less bone formation, low bone density, makes RBC

Vitamin K helps..

In general it..

calcium bind to bone proteins, helps blood clot

Vitamin C makes BLANK. Lack of prevents BLANK.

collagen for bone matrix, cross linking of fibers

Vitamin C deficiency is called..what does it do?

Scurvy, cause gums to bleed

Vitamin D does what?

lets intestines absorb calcium, regulate bone mineralization and density

Vitamin D deficiency in children is..what does it do?

Rickets, weakens bones to cause skeletal deformities liked bowed legs

What is Osteomalacia?

Bone softening