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Where does heme synthesis start?
In the mitochondria
What two molecules combine to form ALA?
Glycine and Succinyl CoA
ALA is the first precursor for Hemoglobin
Where do most intermediate steps of Hemoglobin biosynthesis take place?
Cytoplasm
What is added in the FINAL step to form heme?
Fe2+
Where does heme go after it is formed?
It goes into the cytoplasm where it combines with the globin chains
How many genes control globin production?
6 genes
Which chromosomes control globin genes?
16 & 11
Where are globin chains made?
Ribosomes
What carries instructions from DNA to ribosomes?
mRNA
What combines to form hemoglobin?
Heme + globin