Cytochrome P450 Enzyme Substrates: Pharmacology and Drug Metabolism
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15 Terms
cyp 1a2 substrate?
tizanidine
CYP 2D6 substrate?
Desipramine, paroxetine, fluvoxamine, codeine, tramadol, hydrocodone
CYP3A4/5 substrate?
tacrolimus, quetiapine
CYP 2A6 substrate?
Nicotine
CYP 2B6 substrate?
Sertraline, Efavirenz Methadone
CYP 2C8 substrate?
Rosiglitazone, Repaglinide, Ibuprofen, Pioglitazone
CYP 2C9 substrate?
NSAIDs, Phenytoin, S-Warfarin
CYP 2C19 substrate?
Clogidogrel, PPIs, Sertraline, Escitalopram, Citalopram, Voriconazole
What CYPS does Rifampin induce?
CYP 2C8, CYP 2C9, CYP 2C19, CYP 3A4/5, CYP 2B6
What CYPS does St John's Wort induce?
CYP 2C8, CYP 2C9, CYP 2C19, CYP 3A4/5, CYP 2A6
What drugs induce CYP 3A4/5?
Carbamazepine, Phenobarbital, Phenytoin, Troglitazone, St John's wort, Rifampin
What CYP is Efavirenz both an inducer and substrate for?
CYP2B6
Which CYPs have no inhibitors that we have to know?
CYP 2B6, CYP 2A6, CYP2C8
Inhibitors of CYP 2D6?
Bupropion, Fluoxetine, Duloxetine, Quinidine
Inhibitors of CYP 2C9?
Amiodarone, Microzole, and Fluconazole