Adverse Effects of Pharm 2 Meds

Cyclophosphamide

hemorrhagic cystitis, nadir

Doxorubicin

cardiotoxicity, vesicant, red/orange urine

Cisplatin

nephrotoxic, ototoxic, emetogenic

Methotrexate

autoimmune, leucovorin, renal precipitation

3% NaCl

osmotic demyelination, vesicant,

Demeclocycline

photosensitivity, GI upset, hepatic & renal toxicity, not for pregnancy or kids, can cause superinfection

Desmopressin (DDVAP) SE/AE

water intoxication, HTN, seizures, headache, congestion, flushing

Desmopressin Contraindicated for…

nephrogenic DI, hyponatremia, renal insufficiency, HF

PTU & Methimazole

hepatotoxic, agranulocytosis, GI upset, arthralgia, rash

Levothyroxine

hyperthyroid symptoms, Afib, adrenal crisis

Antihistamines (Diphenhydramine & Hydroxyzine)

sedation, antichol, dry mouth, retention, confusion

Mycophenolate

low neutrophils, GI upset, teratogenic, take on empty stomach

Tacromilus

diabetes, nephrotoxic, high K, low Mag, near effects: tremor, headache, confusion, hirsutism, gum overgrowth

Infliximab

get TB & HepB testing, infusion rxns, worsening HF

Tocilizumab

increase liver enzymes, down neutrophils, down platelets, increase cholesterol, monitor for GI perf

Mitoxantrone

cardiotoxic, down neutrophils, blue/green urine