stable angine brand and generic

Drugs used for cardiac stress test

Adenosine

Dipyridamole

Dobutamine

Regadenoson

Aspirin

Bayer Bufferin Ecotrin

Irreversibly inhibits COX-1 COX-2 enzyme, decreases prostaglandin and thromboxane A2

1st line anti platelet/used indefinitely in stable angina

AVOID if pt has NSAID OR SALICYLATE ALLERGY

Reye’s syndrome

Bleeding/GI ulceration (PPIs may be used to protect GI tract

Tinnitus (a sing of salicylate overdose)

Dyspepsia heartburn bleeding nausea (use enteric coated or buffered or take with food to decrease nausea)

Non-enteric coated, chewable aspirin is preferred in ACS (acute coronary syndrome). If enteric coated aspirin is available then it should be chewed 325mg

Aspirin/Omeprazole

Yosprala

Clopidogrel

Plavix

Irreversible inhibit P2Y12-ADP receptor

PRODRUG requires activation by CYP2C19 enzyme. Caution with poor CYP2C19 metabolizers

Used if patient is contraindicated to aspirin

Contraindicated if active serious bleeding

Bleeding risk discontinue 5 days prior surgery

Avoid use with omeprazole and esomeprazole

Causes thrombotic thrombocytopenia purpura TTP

Ranolazine

Aspruzyo Sprinkle

Avoid with CYP3A4 inhibitors and inducers/ liver cirrhosis

QTc prolongation/Acute renal failure CrCl <30ml/min

Not for acute treatment of chest pain, has little to no clinical effects on HR and BO

Add on therapy

Nitroglycerin SL tablet

Nitrostat

Short acting: used PRN for immediate relief on chest pain

Store in original amber glass bottle and keep tightly capped after each use to maintain potency

Place under tongue and let dissolve

Nitroglycerin TL spray

NitroMist, Nitrolingual

Short acting: PRN for immediate relief of chest pain

Nitroglycerin 2% ointment

Nitro-BID

Dosed bid 6 hours apart with 10-12 hours nitrate free interval

Nitroglycerin patch

Nitro-Dur

Wear on for 12-14 hours. Off for 10-12 hours

Rotate sites, preferred on chest except below knees/elbows.

Nitroglycerin ER capsule

Nitro-Time

Isosorbide mononitrate

IR: BID 7 hours apart

ER: Once daily in the morning

Isosorbide dinitrate

Isordil

IR: BID - 7 hours apart

TID - 4 hours apart

(14 hours nitrate free interval or similar must)