HISTONE H1 AND REPRESSIVE MODIFICATION SPREADING (Page 33)

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Last updated 2:10 PM on 6/19/26
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6 Terms

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[What is the role of Histone H1 in chromatin structure?]

Histone H1 is critical to maintain chromatin compaction and 3D genome architecture.

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; [What happens when three Histone H1 coding genes are knocked out?]

Global chromatin decompaction occurs (visible by electron microscopy), with global depletion of repressive histone modifications (H3K27me3) and gains in active histone modifications (H3K36me3) at large scales across chromosomes.

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; [What Hi-C changes occur upon H1 knockout?]

Gains in active A compartments and reductions in repressive B compartments.

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; [How does Histone H1 facilitate repressive histone modification spreading?]

Histone H1 incorporation into the nucleosome facilitates 'spreading' of repressive histone modifications following cell division. H1-mediated compaction of nucleosomal structure at the dyad is essential for normal deposition and maintenance of histone modification landscapes after cell division.

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; [What does this explain about H1 loss?]

This explains the major changes in nuclear structure upon H1 los