Endo Exam 2: Non-Diabetic Drugs DOSING

Glucophage, Glumetza, Fortamet

Initial: 500 mg daily or BID, OR 850 mg daily

Titration: Titrate by 500 mg increments

Max Dose: Usually 2000 mg

Metformin IR/XR

Diabeta, Glynase, Micronase

Initial: 2.5 mg daily

Titration: Increase by 2.5 mg weekly

Max Dose: 20 mg/day

Glyburide

Glucotrol, Glucotrol XL

Initial: 5 mg daily

Titration: IR: increase by 2.5–5 mg every 1–2 weeks. ER: increase by 5–10 mg once weekly

Max Dose: 40 mg (20 mg for XL)

Glipizide

Amaryl

Initial: 1 mg daily

Titration: Increase by 1–2 mg every 1–2 weeks

Max Dose: 8 mg

Glimepiride

Starlix

Initial: 60–120 mg TID with meals

Nateglinide

Prandin

Initial: 0.5 mg TID with meals if A1C <8%, 1–2 mg TID if A1C >8%

Titration: May double the dose at each meal at intervals of ≥1 week

Max Dose: 4 mg/dose or 16 mg/day

Repaglinide

Actos

Initial: 15 mg daily

Max Dose: 45 mg daily

Pioglitazone

Nesina

Initial: 25 mg daily

Max Dose: 25 mg

Alogliptin

Tradjenta

Initial: 5 mg daily

Max Dose: 5 mg

Linagliptin

Onglyza

Initial: 2.5 or 5 mg daily

Max Dose: 5 mg

Saxagliptin

Januvia

Initial: 100 mg daily

Max Dose: 100 mg

Sitagliptin

Precose

Initial: 25 mg TID (quarter)

Titration: Increase at 4–8 week intervals to a maintenance dose of 50–100 mg TID

Max Dose: ≤60 kg: 50 mg TID. >60 kg: 100 mg TID

Acarbose

Glyset

Initial: 25 mg TID

Titration: Increase at 4–8 week intervals to 50 mg TID, then after 3 months may increase to 100 mg TID

Max Dose: 100 mg TID

Miglitol

Trulicity

Initial: 0.75 mg SC weekly

Titration: To 1.5 mg, then 3 mg after ≥4 weeks on 1.5 mg, then 4.5 mg after ≥4 weeks on 3 mg

Max Dose: 4.5 mg weekly

Dulaglutide

Ozempic

Initial: 0.25 mg weekly x 1 month

Titration: To 0.5 mg, then 1 mg after 4 weeks, then 2 mg after ≥4 weeks on 1 mg

Max Dose: 2 mg weekly

Semaglutide SC

Initial: 1.5 mg daily x 30 days

Titration: To 4 mg daily, then 9 mg daily if needed

Max Dose: 9 mg daily

Semaglutide oral

Victoza

Initial: 0.6 mg SC daily x 1 week

Titration: To 1.2 mg daily

Max Dose: 1.8 mg daily

Liraglutide

Mounjaro

Initial: 2.5 mg SC weekly x 4 weeks (not an effective glycemic dose, it’s to limit GI effects)

Titration: To 5 mg, then increase by 2.5 mg every 4 weeks as needed

Max Dose: 15 mg weekly

Tirzepatide

Invokana

Initial: 100 mg daily

Max Dose: 300 mg daily

Canagliflozin

Farxiga

Initial: 5 mg daily

Max Dose: 10 mg daily

Dapagliflozin

Jardiance

Initial: 10 mg daily

Max Dose: 25 mg daily

Empagliflozin

Steglatro

Initial: 5 mg daily in the AM

Max Dose: 15 mg daily

Ertugliflozin

Brenzavvy

Initial: 20 mg daily in the AM

Max Dose: 20 mg daily

Bexagliflozin

Initial: 3.75 g/day (6 tablets once daily, or 3 tablets BID, with meals)

Colesevelam (Welchol)