412 Pharmacokinetic Effects

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Last updated 9:14 AM on 10/1/26
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8 Terms

1
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Codeine

CYP2D6
Metabolized to morphine
do not use for UM and PM

2
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Warfarin (Coumadin)

CYP2C9 2 and 3
Warfarin accumulation higher bleeding risk
Lower dose

3
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Phenytoin (Dilantin)

CYP2C9
Phenytoin accumulation skin disease
Use alternative or dose reduction

4
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Clopidogrel (Plavix)

CYP2C19 2 and 3
Product clotting risk
Use alternative like prasugrel

5
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Irinotecan (Camptosar)

UGT1A1
SN-38 accumulation severe side effects
Dose reduction
PGx recommended

6
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Azathioprine (Azasan)

TPMT
active drug accumulation and life-threatening myelosuppression
Lower dose or alternative drug
PGx recommended

7
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Capecitabine (Xeloda) and 5-FU

DPD or DPYD
drug accumulation drug toxicity
50% dose reduction

8
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Statins (Prava, Atorva, Simva)

OATP1B1
SLCO1B1
Myopathy
Change to rosuvastatin