Advanced Pharm Test 1

amoxiCILLIN

Gram +
Adverse: NVD, nephrotoxic, superinfection
Interactions: aminoglycoside, contraceptives

CEPHalexin

Gram + and -

Crosses blood-brain barrier

Adverse: psuedomembranous colitis, nephrotoxic, NVD
Interaction: alcohol

ertaPENEM

Gram + and -

Adverse: GI, c diff, pseudomembranous colitis

Interaction: seizure meds

ciproFLOXACIN

Gram -

Adverse: superinfection, tendon rupture, photosensitivity

Interactions: mineral supplements, corticosteroids

doxyCYCLINE

Gram + and -

Adverse: photosensitivity, GI, teeth/bone discoloration (not for children under 8)

Interactions: mineral supplements and food, birth control

Gentamycin

Gram -

Adverse: ototoxic, nephrotoxic, trough levels

Interactions: diuretics, pencillins/cephalosporins

Vancomycin

Gram + and MRSA

Adverse: ototoxic, nephrotoxic, superinfection, red man syndrome

Interaction: nephrotoxic/ototoxic drugs

Erythromycin

Gram +

Adverse: QT interval V tach risk, ototoxic

Interactions: carbamezpaine, digoxin, warfarin, calcium channel blocker, antiretroviral

SULFAmethoxazole-trimethoprim

Gram + and -

Teratogenic from profound jaundice

Adverse: crystalluria/nephrotoxic, hyperkalemia, photosensitivity

Rifampin

Mycobacterium tb

Adverse: hepatotoxic, orange body fluids, superinfections

Interactions: many

Osteltamivir

Treats flu

Decrease CNS dopamine → lethargy, vasodilation, dizziness, hypotension, NV, mood

Acyclovir

Treats herpes: STIs + shingles

Kidneys, not liver metabolize

Adverse: AKI, dermatitis with topical, depression, hair loss

Contraindivations: pregnancy, renal disease

Interactions: nephrotoxic drugs

zidovudine

Treats HIV

Adverse: bone marrow suppression, flu-like syndrome without temp, fatty liver

Contraindication: pregnancy due to lactic acidosis

Interactions: many

KetoconAZOLE

antifungal

Systematic adverse: hepatotoxic, irregular menses, decreased libidio, gynecomastia

Interactions: many

Amphotericin B

BIG GUN

Adverse: nephrotoxic, myelosuppression, infusion reaction, thrombophlebitis

Chloroquine

anti-malaria

Adverse: NVD, hepatotoxic

Contraindication: liver disease, alcohol, caution Mediterranean descent (hemolytic crisis)

MetronidAZOLE

anti-protozoan

Adverse: dizziness, ataxia, NVD, hepatotoxic, dark urine normal
Interactions: alcohol, warfarin

Cisplatin

Chemo drug

Adverse: GI, alopecia, myelosuppression, nephrotoxic, hemoorhagic cystitis (!!), infertility

Doxorubicin

red devil…

Adverse: GI/alopecia/myelosuppression, CARDIOTOXIC, urine/tears red for 48 hours

Administered via buried port because vesicant.

Protect yourself.

Methotrexate

Adverse: GI/myelosuppression/nephrotoxic/alopecia, CNS suppression, NEURO

Tamoxifen

Antagonizes estrogen over 3-5 years

Adverse: menopausal symptoms, DVT risk, menstrual irregularities, decreased visual acuity, cataracts

Contraindication: pregnancy