WBC abnormalities

Pelger Huet Anomaly

Autosomal dominant disorder

Pelger Huet Anomaly

hyposegmentation

Pelger Huet Anomaly

round oval/bilobed nuclei

spectacle-like

pince-naz-like

dumbell or peanut chromatin

Pseudo-Pelger-Huet Anomaly

acquired anomaly

Pelger Huet Anomaly

also described as blood laminopathy (lamin B receptor)

Hyposegmentation

polycytes/macropolycytes

Hyposegmentation

“myeloid right shift”

Hyposegmentation

abnormal DNA synthesis

megaloblastic states

cytoplasmic abnormalities

Alder-Reilly

accumulation of degraded mucopolysaccharides

Chediak-Higashi

formed by the aggregation and fusion of the primary and secondary specific granules

Chediak-Higashi

neutropenia

thrombocytopenia

albinism

Chediak-Higashi

mutation in the LYST gene

Dohle bodies

aggregates of free ribosomes of rER

Dohle bodies

confused with may-hegglin

May-Hegglin

thrombocytopenia

May-Hegglin

derived from RNAMay-Hegglin

May-Hegglin

mutation of MYH9 gene

Toxic Granules

increased accumulations of granules

Toxic Granules

poor prognosis

Auer Rods

fused primary granules

Auer Rods

leukemia

Auer Rods

myeloperoxidase test +

LE cell

autoimmune disorder

LE cell

increased immune activity in the body

LE cell

from phagocytosis of apoptotic bodies induced by autoantibodies

Tart cell

monocyte with ingested lymphocyte