Top 200 injectable

Abatacept

Brand name: Orenica

Use: RA, Juvenile Idiopathic Arthritis, Prophylaxis of acute Graft-versus-host disease(GVHD)

MOA: inhibits T-cell activation by interrupting the costimulatory interaction between CD28 on the T cell and CD80/CD86 on the antigen-presenting cell

Adalimumab

Brand Name: Humaria

Use:

• Ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis

• Crohns disease & Ulcerative colitis

• Plaque psoriasis

• Hidradenitis suppurativa

• Juvenile idiopathic arthritis:

MOA: blocks tumor necrosis factor-alpha (TNF-alpha)

BBW: Malignancy, serious infections

Adenosine

Brand: Adenocard

Use: Paroxysmal supraventricular tachycardia

MOA: Decelerates conduction time through AV node, interrupts re-entry pathways through AV node, and restores normal sinus rhythm.

CI: 2nd- or 3rd-degree AV block, sinus node disease

Ado-Trastuzumab

Brand name: Kadcyla

MOA: anti-HER2 antibody

Use:

• HER2-positive, metastatic breast cancer (as single agent) in patients who previously received trastuzumab and a taxane, separately or in combination

• Adjuvant treatment for HER2-positive early breast cancer who have residual invasive disease after neoadjuvant taxane and trastuzumab-based therapy

BBW: Hepatotoxicity, cardiotoxicity, embryo-fetal toxicity

Alemtuzumab

Lemtrada

Use:

• B-cell chronic lymphoid leukemia

• Relapsing remitting multiple sclerosis(RRMS):

MOA: Depletion of T and B lymphocytes by binding cell surface CD-52

Alteplase

Brand name: Activase

MOA: Initiates fibrinolysis by binding to fibrin in a thrombus and converts entrapped plasminogen to plasmin.

Use: Acute ischemic stroke within 3 h of symptom onset, Acute pulmonary embolism, STEMI in a facility without PCI capability, central venous catheter clearence

CI:

• Active internal bleeding

• recent intracranial or intraspinal surgery or trauma within 2 mo

• Any prior intracranial hemorrhage

• ischemic stroke within 3 mos

• severe uncontrolled hypertension

• current use of anticoagulants with elevated laboratory tests (eg, INR >1.7, etc)

• thrombocytopenia

• acute bacterial endocarditis

AMIVANTAMAB-vmjw

Brand name: Rybrevant

MOA: Bispecific antibody that targets both EGFR and mesenchymal-epithelial transition (MET).

Use: Non–small-cell lung cancer(with GFR mutation)

Amphorectin B

MOA: Alteration of cell membrane permeability through binding to ergosterol; fungicidal.

Use:

• Aspergillus species, Candida species, or Cryptococcus species

Prefer liposomal formulation in renal impairment

AMPICILLIN/SULBACTAM

Brand name: Unasyn

MOA: beta lactam

Covers:

• Beta-hemolytic Strep (pyogenes, agalactiae

• Susceptible Enterococcus

• MSSA Coverage

• Gram - Anerobes( B. fragilis )

• Acinetobacter

ADRs: GI upset, hypersensitivity, and seizures

Does not cover MRSA or Pseudo

ANGIOTENSIN II

Brand name: Giapreza

Use: Septic or distributive shock

MOA: Synthetic version of the angiotensin —>Causes vasoconstriction and increases aldosterone release, which raises blood pressure.

ARGATROBAN

MOA: Direct Thrombin Inhibitor

Use: HIT, Percutaneous coronary intervention

CI: Major, active bleeding

ARSENIC TRIOXIDE

Brand name: Trisenox

Use: Acute promyelocytic leukemia(newly diagnosed or refractory) in presence of a t (15:19) translocation

MOA: Damages or degrades the fusion protein promyelocytic leukemia (PML)-retinoic acid receptor (RAR) alpha.

ATEZOLIZUMAB

Brand Name: Tecentriq

Use:

• Non–small-cell lung cancer and small cell lung cancer

• BRAF V600 mutation

• combination with bevacizumab

MOA: PD-L1 on the surface of tumor cells and blocks the interaction of T cells and antigen-presenting cells which releases the inhibition of the immune response and activates the antitumor response.

Atropine

Brand name: Atropen

MOA: Blocks acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and the CNS; increases cardiac output, dries secretions.

Use:

• bradycardia

• cholinergic OD

CI: Asthma, glaucoma, tachycardia

AXICABTAGENE CILOLEUCEL

Brand Name: Yescarta

MOA: modified autologous T cell that is directed toward the CD19 antigen on B-lymphocytes.

Use: B-cell lymphoma after failing two lines of therapy

BBW: Cytokine release syndrome, neurological toxicity, REMs, T-cell malignancies

AZACITIDINE

Brand Name: Vidaza

MOA: a pyrimidine nucleoside analog of cytidine

Use: Anemia, leukemia

CI: malignant hepatic tumors

AZTREONAM:

Azactam

MOA: monobactam that binds to penicillin binding proteins (PBP) and interferes with cell wall synthesis for sensitive bacteria

Has activity against Gram negative bacteria ONLY, like Pseudomonas aeruginosa

BENDAMUSTINE:

Brand name: Belrapzo, Bendeka, Treanda,

MOA: bifunctional nitrogen mustard derivative containing a purine-like benzimidazole ring. It covalently bonds to DNA, leading to DNA crosslinking and cell death.

Use: leukemia, lymphoma

CI: History of hypersensitivity to bendamustine, polyethylene glycol 400, propylene glycol, monothioglycerol

BEVACIZUMAB

Brand name: Avastin, Mvasi, Vegzelma, Zirabev

MOA: Binds to and neutralizes soluble VEGF, preventing its binding to endothelial receptors Flt-1 and KDR. Inhibition of VEGF binding prevents angiogenesis, thereby slowing tumor growth.

BEZLOTOXUMAB

Brand name: Zinplava

Use: Secondary prevention of C. difficile infection:

MOA: Monoclonal antibody binds to C. difficile toxin B which prevents toxic effects. How this prevents recurrent infections is unknown.