Dna acid inhibitors,protien synthesis inhibitors and folic acid -

Types of DNA inhibitors?

Dna damagers-produce nitric oxide

Nitromidazoles and nitrofurantoin

Dna gyrase inhibitors-FQ

inhibit dna replication

Moa of nitromidazoles and longest acting?

1-nitric oxide production in bacteria

2-inhibits PFOR enzyme in protozoa

Longest-Secnidazole.

Use of metro?

T/t of all anerobic batceria

Doc:Giardiasis,Entamoeba,Trichomonas vaginalis,Dracunculus,Gardneralla

S/E of metro and use in pregnancy

1-Disulfiram like reaction-C/I in alcoholic

Not seen w satranidazole

2-Brown urine

3-all nitro drug s c/I in G6PD def

Pregnancy-not in T1,given in T2,T3.

Benznidazole

Doc for Chagas dx

Nitazoxanide

Doc for Cryptosporidium parvum

1st gen Fq

only for Gram -ve

1-Norfloxacin

2-Ofloxacin

3-Cipro

4-Peflo

Norfloxacin use,

Doc for SBP

Ciprofloxacin is not combined w warfarin or theophylinne?

CYP inhibitor-increase toxicity of warfarin-Bleeding, or theophyline-Seizures.

Fq with max oral absorption?

Levofloxacin-100%BA

Renal failure safe FQ

Pefloxacin(max cns penetration)

Moxifloxacin-most effective in TB

Trovafloxacin-banned,d/t hepatotoxic

Longest FQ and it’s S/E

Sparfloxacin

S/e-max risk for Qt prolongation,max incidence of photo toxicity

Main s/E of FQ

Rupture of achiless tendon in elderly.

Main s/E of FQ

Rupture of achiless tendon in elderly.

Nitrofurantoin is effective against?

UTi causes d/t E.Coli-it is only effective in acidic urine.

Protein synthesis inhibitors are of how many types?

1-Inhibit attachment-Tetracycline(30s)

2-inhibit translocation-Macrolides,clinda,streptogramin(50s)

3-inhibits peptide formation-chloramphenicol(50s)

4-inhibits protein synthesis-Linezolid(50s)

5-multiple mechanisms-Aminoglycosides(30s)

Only tetra safe to use in renal failure

Doxycycline

Uses of doxy?

1-Treatment of cholera

2-Chalmydia-+Azithro 1g single dose

3-Rickettsia-+ azithro

4-Borrelia

5-Lepto-

Tetracycline used for treatment of SIAdh

demeclocycline

C/I of tetra

1-Pregnacy

2-children less than 8 years-cause teeth discoloration

3-Liver failure

4-Renal failure except Doxy

Macrolides avoided in Neonates

Erythromycin and Clarithromycin-causes hypertrophic pyloric stenosis.

Safe in pregnancy and children less than 8 years.

Which drug is most effective in treatment of H.Pylori infection?

Clarithromycin

Doc of toxoplasma infection in pregnancy

Spiramycin

Doc for organ transplantation?

Tacrolimus-Immunosuppressant drug