BISC 102 - Pedigrees (and practice)

key points from this lecture...

In pedigrees _____ are XY and ______ are XX.

male, female

“affected” individuals (with phenotype of interest) are _______; “non-affected” individuals are not ______

shaded in

Individuals who are unaffected phenotypically, but have the allele of interest are called _____.

carriers

Define “autosomal recessive”.

gene is on an autosome, and is recessive.

Define “autosomal dominant”.

gene is on an autosome, and is dominant.

Define “x-linked recessive”.

gene is sex-linked and recessive.

In the case of autosomal recessive: If two unaffected parents have an unaffected child, the trait must be ____.

recessive

If an affected XX child does not have an affected father, it must be ______.

autosomal

In the case of autosomal recessive: Two affected parents cannot have an _____ child

unaffected

In the case of autosomal dominant: every affected child must have an ______ parent

affected

In the case of autosomal dominant: approximately ___ of offspring (both XX and XY) from an affected parent will be affected

50%

In the case of autosomal dominant: two affected parents can have an _____ child

unaffected

In the case of X-linked recessive: affected ___ individuals are more common

XY

In the case of X-linked recessive: all affected ___ individuals must have an affected XY parent

XX

In the case of X-linked recessive: affected XY individuals must have inherited their affected X chromosome from their ___ parent

XX