Bloodbank Lecture 2 EXTERNAL INNATE IMMUNITY

What is our Innate Immunity?

• NON SPECFIC

• NO MEMORY NEEDED NOR GENERATED

Body’s innate ability to defend itself

EITHER EXTERNAL OR INTERNAL

What are the different kinds of EXTERNAL Defense Systems

1. Skin

2. Mucous Membranes

3. Respiratory Tract

4. Digestive Tract

5. Genitourinary Tract

6. Microbiota

What are the two layers of the SKIN

1. Epidermis

   1. epithelial cells OUTER MOST

2. Dermis

   1. Connective tissue, WBCs, blood vessels, etc

What makes the SKIN a defense?

• pH OF 5.6

  • Lactic acid and fatty acid secretions

• Antibacterial proteins

Where can MUCOUS MEMBRANES be found

• Respiratory tract

• Digestive tract

• genitourinary

What makes the MUCOUS MEMBRANES a good defense?

• Excretion of SURFACTANS

  • prevent pathogens/bacteria from attaching to epithelial cells

• WORK WITH CILIA to sweep pathogens out

• PHYSICAL BARRIER

What are the primary defenses of the Respiratory Tract?

• COUGHING and SNEEZING

• CILIA which sweep debris

What makes the DIGESTIVE TRACT a good defense?

• pH levels

  • stomach is very acidic pH 1

• LYSOZYMES attacking bacterial cell walls

What defenses are associated with the GENITOURINARY TRACT?

• URINE flushing out pathogens

• lactic acid keeping relative low pH of 5

How does the MICROBIOTA defend?

• COMPETES with pathogens

  • dont allow for pathogens to settle in body