CHAPTER 4 Red Blood Cell Disorders

African trypanosomiasis, microscopic

Filariasis, microscopic

Babesiosis, microscopic :

Shown here are a characteristic tetrad ( ) and ring forms ( )

Leishmaniasis, microscopic:

Seen here are multiple amastigotes of Leishmania donovani infantum in a bone marrow smear.

Borreliosis, microscopic:

This peripheral blood smear shows multiple Borrelia recurrentis organisms

Malaria, microscopic :

Shown here are ring forms of P. vivax in RBCs

Myelofibrosis with teardrop cells, microscopic:

This peripheral blood smear shows teardrop cells

Microangiopathic hemolytic anemia, microscopic:

irregularly shaped cells, such as helmet cells

Marrow granuloma, microscopic:

*granuloma

Myelophthisic anemia, microscopic:

The marrow spaces between the reactive woven bone

Aplastic anemia

Basophilic stippling, microscopic

Hypochromic anemia, microscopic

Megaloblastic anemia, microscopic:

macro-ovalocytes

α-Thalassemia major, capillary electrophoresis

α-Thalassemia major, microscopic:

polychromasia ( ), nucleated RBCs ( ), and even erythroblasts ( ).

β-Thalassemia major, radiograph

β-Thalassemia major, gross

β-Thalassemia major, hemoglobin electrophoresis

β-Thalassemia major, microscopic

Hemoglobin E disease, capillary electrophoresis

Hemoglobin SC disease, microscopic

Howell-Jolly bodies, microscopic

Sickle cell anemia, gross

Sickle cell anemia, microscopic:

sickled RBCs

Hemoglobin electrophoresis, cellulose acetate

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, microscopic:

shows RBC Heinz body inclusions

Hereditary spherocytosis, microscopic

Hemolytic anemia, microscopic:

RBCs lacking central pallor—spherocytes

Rouleaux formation, microscopic

Normal peripheral blood smear, microscopic

Normal bone marrow smear, microscopic:

megakaryocytes ( ), erythroid precursors ( ), and granulocytic precursors ( )

Normal bone marrow, microscopic:

megakaryocytes ( ), erythroid islands ( ), and granulocytic precursors ( ) are present

Normal bone marrow, microscopic:

The erythroid islands ( ) and granulocytic precursors ( ) form the bulk of the hematopoietic components, admixed with steatocytes ( ). The large multinucleated cells are megakaryocytes ( ).