BIOL 5500 - Case Studies Related to B Cell Development

What leads to increased susceptibility to extracellular bacterial pathogens?

Antibody Deficiency

What do extracellular bacterial pathogens cause?

Pyogenic Infections

When there is a decrease in T cells and B cells what is the condition?

Severe combined immunodeficiency (SCID)

Mutations in which genes can cause SCID?

Genes in Somatic Recombination

In SCID, specifically for this patient where were the mutations?

RAG2 genes

The development and function of which cell does not depend on RAG proteins?

NK cells

In X-Linked Agammaglobulinemia, which types of cells are affected?

B Cells

What antibody tags B cells?

CD19

Which antibody tags T cells?

CD3

XLA is caused by a mutation in what?

Bruton’s Tyrosine Kinase (BTK)

What contributes to singling from the BCR and is required for the growth and differentiation of Pre-B cells?

BTK

When does the B cell become arrested?

pre-B cell stage

Signals from a properly assembled Pre-B cell receptor induces what at other heavy chain locus?

Allelic exclusion

What takes place of rearranged light chain and allows testing of heavy chain?

Surrogate Light

What is required for signaling through BCR and Pre-BCR?

BTK

No B cells means what is not being produced?

Antibodies