Protein Function and Evolution

Which Protein is considered a representative of the R state and Which protein is able to fluctuate between T & R state?

myglobin; Hemoglobin

The protein whose function is to transport oxygen to the muscle tissue is called?

Hemoglobin

The most direct factor that influences the binding of oxygen to myoglobin is

the partial pressure of oxygen

Heterotropic effectors that modulate hemoglobin binding of oxygen are

molecules like carbon dioxide and 2,3-BPG, and H+

What is the primary function of hemoglobin?

Transport oxygen to the muscle tissue and carbon dioxide back to the lungs.

What are the physiological implications of altered hemoglobin affinity for oxygen in response to varying environmental conditions?

Changes in hemoglobin's affinity for oxygen, influenced by factors such as altitude or pH levels, can affect oxygen delivery efficiency to tissues and overall metabolic function during stress or adaptation.

Neuroglobin (Ngb)

found in nerve cells and retina and believed to protect neurons from hypoxic injury

Cytoglobin (Cygb)

found in fibroblasts believed to facilitate O2 diffusion, scavenge ROS and collagen synthesis

Androglobin (Adgb)

Found in mammalian testis and required for sperm flagellum formation

What site does the iron component of heme bind to? What is the name of the histidine?

5th coordination site is bound to imidazole ring of His93 called Proximal histidine

What site does the other iron component of heme bind to? What is the name of the Hb?

6th coordination site is unoccupied in deoxyHb and bound to oxygen in oxyHb (or Mb)