IP 7 Lecture 4 - Pain Pathophysiology | Mechanism of Action
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23 Terms
Salicylates / Acetylsalicyclic acid / ASA
Non Competitive & Irreversible COX 1 & COX 2 Inhibitor via Acetylation
Ibuprofen
Ketoprofen
Reversible & Non Selective COX 1 & COX 2 Inhibitor
Diclofenac
Reversible & Non Selective COX 1 & COX 2 Inhibitor
Ketorolac
Reversible & Non Selective COX 1 & COX 2 Inhibitor
Naproxen
Reversible & Non Selective COX 1 & COX 2 Inhibitor
Celecoxib
Reversible & COX 2 Selective (> COX 1) Inhibitor
Acetaminophen / APAP
Central PGE Production / 5HT Modulation
Ketamine
Noncompetitive NMDA Antagonist
Dissociative Anesthetic
Suzetrigine
Selective NaV 1.8 Inhibitor
(AP Inhibitor in the peripheral nociceptive neurons)
Tramadol
MuOR Full Agonist & 5HT / NE Reuptake Inhibitor
Tapentadol
MuOR Full Agonist & 5HT / NE Reuptake Inhibitor
Loperamide
Peripherally-restricted opioid agonist with poor bioavailability
Buprenorphine
MOR Partial Agonist
& KOR Weak Antagonist
Naloxone
Opioid Antagonist with no oral bioavailbility
Naltrexone
Opioid Antagonist
Methylnaltrexone / Naloxegol
Opioid Antagonist Adjuvent used for preventing opioid-induced constipation
Nalmefene
Opioid Antagonist
Gabapentin
Binds to the α2-δ subunit of Voltage Gated Calcium Channels to reduce NTM release
Pregabalin
Binds to the α2-δ subunit of Voltage Gated Calcium Channels to reduce NTM release
Carbamazepine
Inhibit Voltage Gated Sodium Channels
Desipramine
Inhibit NE & 5HT Reuptake Inhibitor
& Blocks Na, Ca Channels
& Blocks NMDA receptors
Nortriptyline
Inhibit NE & 5HT Reuptake Inhibitor
& Blocks Na, Ca Channels
& Blocks NMDA receptors
Duloxetine
Selective NE & 5HT Reuptake Inhibitor