T cell mediated immunity

Initial T cell responses occur within a______

Secondary lymphoid tissue

T cells enter lymph node across _____ in the cortex

High endothelial venules

T cells that encounter specific antigen in the node proliferate and differentiate into _____

Effector cells

Signal 1 is delivered through _____ after binding to MHC/Peptide

TCR

Signal 2 is delivered through ______ after binding to co-stimulatory molecule _____

Delivered through CD28, binds to B7

Stimulation through both ____ and ____ is required for normal T cell activation

CD3 and CD28

What are the two forms of B7

CD80 and CD86

What does differentiation of a naive T cell into an effector cell depend on ?

Cytokine interleukin 2 (IL2)

Naive T cells express the ______ receptor

Low affinity IL-2 receptor

Activated T cells express the _____ receptor

high affinity IL-2 receptor

Signal sent from the IL2 receptor induces ____

proliferation