General Pathology: Intracellular Accumulations of Proteins and Glycogen

Vocabulary flashcards reviewing intracellular accumulations of proteins and glycogen from Chapter 8 of General Pathology.

Proximal tubular hyaline droplets

Pink hyaline droplets formed in the cytoplasm of proximal tubular epithelial cells on H & E-stained sections due to excessive renal tubular reabsorption of proteins in proteinuria; reversible when proteinuria is controlled.

Russell bodies

Pink hyaline inclusions found in the cytoplasm of actively functioning plasma cells representing synthesised immunoglobulins.

al-antitrypsin deficiency

A condition characterized by eosinophilic globular deposits of a mutant protein within the cytoplasm of hepatocytes.

Mallory body (alcoholic hyaline)

An intracellular accumulation of intermediate filaments of cytokeratin that appears as amorphous pink masses in hepatocytes.

Amyloid

An abnormal pale yellow proteinaceous substance that forms primarily as an extracellular deposition.

Intracellular glycogen accumulation in diabetes mellitus

Accumulation of intracellular glycogen resulting from impaired normal cellular uptake of glucose, which produces clear vacuoles in the cytoplasm of affected cells in routine H&E-stained sections.

Anatomic sites of glycogen deposition in diabetes mellitus

The epithelium of the distal portion of the proximal convoluted tubule and descending loop of Henle, hepatocytes, beta cells of pancreatic islets, and cardiac muscle cells.