Cellular Reproduction: Chromosomal Rearrangements

Practice flashcards covering chromosomal rearrangements, the Philadelphia chromosome, and cell cycle regulation.

What can happen to portions of DNA when the chromosomes of cells become broken?

They may become rearranged by being lost, scrambled, or duplicated.

What specific chromosomal abnormality causes $95\%$ of cases of chronic myelogenous leukemia?

The Philadelphia chromosome

How does the Philadelphia chromosome form?

It results from a translocation between chromosomes 9 and 22.

What percentage of chronic myelogenous leukemia cases are caused by the Philadelphia chromosome?

$$95\%$$

How can a chromosomal translocation cause cancer?

It can cause cancer when it disrupts the genes that regulate the cell cycle.