activation of rhodopsin (BMED 5207 exam 4)

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5 Terms

1
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step 1 of activation of rhodopsin

activation of G-alpha-t, sequestering inhibitory gamma subunits of cGMP PDE

2
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step 2 of activation of rhodopsin

cGMP second messenger is reduced

3
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step 3 of activation of rhodopsin

the cGMP gated cation closes

4
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step 4 of activation of rhodopsin

the cell becomes hyperpolarized and neurotransmitter release is decreased

5
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signaling of activation of rhodopsin is down regulated by what?

RGS9-G(Beta)5 (GAP); rhodopsin kinase and arrestin; calcium sensitive guanylyl cyclase activating protien (increases cGMP when calcium is low)