Non-Hodgkin Lymphoma Lecture Review

Fill-in-the-blank practice flashcards covering epidemiology, classification, pathogenesis, diagnosis, clinical presentations, and subtypes of Non-Hodgkin Lymphoma.

Non-Hodgkin lymphomas are derived from mature B cells in approximately __________ of cases.

85%

Unlike Chronic Lymphocytic Leukemia (CLL) which affects peripheral blood and bone marrow, Non-Hodgkin lymphoma predominantly affects __________.

lymph nodes, other lymphoid tissues, or extranodal sites

In Western countries, Non-Hodgkin lymphoma accounts for __________ of all lymphoma cases.

85–90%

Low-grade lymphomas are typically indolent and difficult to cure, whereas high-grade lymphomas are aggressive, require urgent treatment, and are more often __________.

curable

Over 60–70% of patients with Diffuse Large B-Cell Lymphoma (DLBCL) are cured with first-line rituximab and __________ chemotherapy.

CHOP

Primary mediastinal B-cell lymphoma is a rare high-grade lymphoma that arises in the __________ and predominantly affects young women.

thymus

Follicular lymphoma accounts for approximately 25% of NHL cases and has a median survival from diagnosis of roughly __________.

20 years

A characteristic complication of Lymphoplasmacytoid lymphoma (Waldenström macroglobulinemia) is __________.

hyperviscosity syndrome

Unlike Mycosis fungoides where tumor cells do not circulate in the blood, Sezary syndrome is characterized by generalized erythroderma, lymphadenopathy, and circulating __________.

T-lymphoma cells

Gastric marginal zone lymphoma of MALT type can be induced by infection with __________.

H. pylori

Epstein-Barr virus (EBV) infects B cells by binding to __________ receptors, establishing a latent infection in memory B cells.

CD21

Besides the bone marrow, the gastrointestinal tract (GIT) is the most common __________ site involved in Non-Hodgkin lymphoma.

extranodal

The microscopic examination of Burkitt lymphoma typically demonstrates a __________ pattern created by numerous tingible body macrophages.

starry sky

The pathognomonic chromosomal translocations required for definitive diagnosis of Burkitt lymphoma involve t(8;14), t(2;8), or __________.

t(8;22)

In the endemic variant seen in Africa, Burkitt lymphoma typically presents in young children (4–7 years old) as a __________ mass.

jawbone

The sporadic variant of Burkitt lymphoma commonly presents in children and young adults as an __________ mass.

abdominal

Diagnosis of Burkitt lymphoma is considered a medical emergency because the tumor exhibits a very high proliferation rate and an extremely short __________.

doubling time

Staging of Non-Hodgkin lymphoma is performed using a __________ scan.

PET/CT