Blood Bank Quiz 3

Antibodies in which blood group system frequently drop in titer and are often implicated in delayed hemolytic transfusion reactions?

Kidd

The antigens in this blood group system are present on the aquaporin 1 molecule, a transmembrane water channel protein on the red cell membrane.

Colton

Which antigens are NOT destroyed by enzymes?

E,

Jka,

P1

Which blood group antigen is found on glycophorin B?

S

These blood group antigens are found on Glycophorin C and D.

Gerbich

Which Lewis phenotype would you expect from a person who is a non secretor with a Le gene?

Le(a+b-)

Which blood group system has two types of (a-b-) phenotypes - one due to a recessive amorph and the other due to a dominant inhibitor gene?

Lutheran

Which best describes anti-I?

It is a benign cold autoantibody

Antibodies to these blood group antigens can be neutralized by human plasma.

Chido/Rogers

This antibody reacts with characteristic shiny refractile agglutinins and can be neutralized by guinea pig urine.

anti-Sda

Which alleles do NOT show dosage?

K / k

Which system antibody can react in any phase of testing?

Lewis

Which of the following system cannot produce High titer, low avidity (HTLA)-like antibodies?

Dombrock

Which antibody can be made by someone who is undergoing dialysis?

Anti-N

Bob the Blood Banker has identified an anti-c and and anti-K in the plasma of Mr. I. M. Anemic. The doctor wants to transfuse 2 units of RBCs. How many units of the Caucasian population must Bob screen to find two compatible units?

11

Which antibody reacts at room temperature, is destroyed by enzymes, and shows dosage?

anti-M

Which antibody is most likely to result in hemolytic disease of the fetus or newborn?

anti-K

This antibody reacts strongly with D+ cells, weakly with D- cells, and not at all with Rh null cells. It's reactivity can be distinguished from anti-D by its inactivity with DTT-treated cells.

anti-LW

Match the antigen(s) to its location or association:

Knops →

Bg →

Cromer →

Sda →

Gerbich →

Chido/Rogers →

Gil →

M →

Knops → C1 complement protein,

Bg → HLA Class I antigens,

Cromer → Decay Accelerating Factor,

Sda → TammsHorsfall glycoprotein,

Gerbich → Glycophorin C,

Chido/Rogers → C4 Complement protein,

Gil → Aquaporin 3,

M → Glycophorin A

Which reactivity best describes a anti-H?

It reacts with adult and cord O cells but not adult or cord A cells

The (a-b-) phenotype in this blood group system results in resistance to the malarial parasite.

Duffy

Which blood group antigens are receptors for the parvovirus B19?

P

Which antibody is an IgG, can cause hemolytic disease of the newborn, is destroyed by enzymes, and reacts with the majority of the Caucasian population?

anti-Fya

This antigen located on glycophorin B, is a high prevalence antigen and has been implicated in transfusion reactions and HDFN.

U

Which antibody is naturally occurring and reacts with loose mixed field agglutinins?

anti-Lua

Individuals with Paroxysmal Nocturnal Hemoglobinuria are negative for these blood group antigens because they are found on the GPI anchor on the RBC.

Dombrock

P2k phenotype can produce which type of antibody/antibodies?

anti-P1, anti- P

Which blood group system is like the ABO system in that the antigens are made by the action of glucosyltransferases?

P

Antibodies in this blood group system are IgG but often bind complement.

Kidd

Which blood group antigen has a higher prevalence in females than in males?

Xga

Which antibody is associated with an Epstein Barr infection?

>anti-i

The antibody in which blood group system is a biphasic hemolysin and associated with Paroxysmal Cold Hemoglobinuria?

P

Which blood group system is associated with a null-like phenotype that more often affects the male population, results in acanthocytes in the peripheral blood smear, and is associated with chronic granulomatous disease?

Kell

Molly the MLS believes she has a Lewis antibody. What can be done to help confirm her findings?

Neutralize the antibody reactivity with the saliva of a secretor